Study on incretin-mediated glucagon secretion in the onset and development of diabetes mellitus
| Project/Area Number |
25460113
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Meiji University of Integrative Medicine |
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Principal Investigator |
KATSURA Masashi 明治国際医療大学, 医学教育研究センター, 教授 (80204452)
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 公道 京都大学, 薬学研究科, 名誉教授 (80025709)
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| Research Collaborator |
SHIGETO Makoto
KAKU Kohei
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | インスリン分泌 / 膵島細胞 / GLP-1 / Aキナーゼ / Cキナーゼ / 膵β細胞 / ＧＬＰ－１ / Ｃキナーゼ / Ａキナーゼ / インクレチン / インスリン / ＰＬＣ / ＰＫＡ / ＰＫＣ / カルシウム流入 / 糖尿病 / グルカゴン / 膵α細胞 |
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| Outline of Final Research Achievements |
Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 directly drives insulin secretion in pancreatic islets. In the present study, we examined the mechanisms by which GLP-1 stimulates insulin secretion in mouse and human islets.
Based on results using high concentration of GLP-1, the mechanism of action of GLP-1 has been considered to be PKA-dependent. But it was revealed that at physiologically low concentration of GLP-1, PKC-dependent pathway promotes insulin secretion.
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Report
(5 results)
Research Products
(11 results)
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[Journal Article] GLP-1 stimulates insulin secretion by PKC-dependentTRPM4 and TRPM5 activation.2015
Author(s)
Shigeto M ,Ramracheya R, Tarasov AI, Cha C-Y, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A, Sones WR, Vergari E, Weston C, Gorelik J, Katsura M, Nikolaev VO, Vennekens R, Zaccolo M, Galione A, Johnson PVR, Kaku K, Ladds G, and Rorsman P
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Journal Title
J Clin Invest
Volume: 125
Issue: 12
Pages: 1-15
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] PKC-dependent activation of TRPM4 channels by physiological concentrations of GLP-1 evokes electrical activity and insulin secretion in mouse and human pancreatic beta-cells.2015
Author(s)
Shigeto M, Ramracheya R, Cha C-Y, Chibalina M, Hastoy B, Philippaert K, Rorsman N, Salehi A, Sones W, Tarasov A, Vergari E, Weston C, Johnson P-R-V, Katsura M, Vennekens R, Gallione A, Kaku K, Ladds G, Rorsman P
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Journal Title
Journal Clinical Investigations
Volume: 125
Pages: 2824-2834
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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