Elucidation for a role of kynurenine pathway on the pathogenesis of depression
Project/Area Number |
25460114
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pharmacology in pharmacy
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Research Institution | National Institute of Radiological Sciences |
Principal Investigator |
Maeda Jun 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (30415426)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | トリプトファン / キヌレニン / 陽電子断層撮像 / うつ病 / ストレス / セロトニン / てんかん / PET / 認知症 / 炎症 / 脳 / 膵臓 / 糖質コルチコイド / アミノ酸トランスポーター |
Outline of Final Research Achievements |
To visualize an incorporation efficiency of tryptophan, a tryptophan analogue [11C]1-methyl-L-tryptopan was synthesized with positron labeling, and the characterization of [11C]1-MT bio-distribution in rodents was investigated using small-animal PET. The uptake of [11C]1-MT in the pancreas was the highest concentration among the organs, while the other organs were relative lower concertation compared to the pancreas. The uptakes of [11C]1-MT in the brain and pancreas were in an active manner, and pretreatment with corticosteroid decreased the cerebral and pancreatic uptakes of [11C]1-MT by 30 %. These results suggested that the uptake of [11C]1-MT was dependent on tryptophan metabolism induced by stress, and indicated that [11C]1-MT was a beneficial marker for diagnosis of depression.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Development of 1-N-(11)C-Methyl-L- and -D-Tryptophan for pharmacokinetic imaging of the immune checkpoint inhibitor 1-Methyl-Tryptophan.2016
Author(s)
Xie L, Maeda J, Kumata K, Yui J, Zhang Y, Hatori A, Nengaki N, Wakizaka H, Fujinaga M, Yamasaki T, Shimoda Y, Higuchi M, Suhara T, Wang F, Zhang MR.
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Journal Title
Sci Rep
Volume: 6
Pages: 11
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.2013
Author(s)
Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
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Journal Title
Neuropsychopharmacology
Volume: 38
Pages: 1409-1425
DOI
Related Report
Peer Reviewed
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