Development of new antitrypanosomal drugs from marine alkaloids
| Project/Area Number |
25460115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Showa Pharmaceutical University (2015)
Hokkaido University (2013-2014) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Jun'ichi 北海道大学, 名誉教授 (90221241)
KATAKURA Ken 北海道大学, 大学院獣医学研究科, 教授 (10130155)
GONOI Tohru 千葉大学, 真菌医学研究センター, 教授 (30134365)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 海洋生物 / 生物活性物質 / アルカロイド / トリパノソーマ / 生物活性天然物 |
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| Outline of Final Research Achievements |
The search for new anti-trypanosomal natural products from marine organisms was performed. As a result, seventeen new natural products were isolated from marine sponges and dinoflagellates, and the structures of new compounds were elucidated. Three new compounds were analogs of anti-trypanosomal natural products previously found by us. These compounds were isolated to analyze the structure activity relationships of anti-trypanosomal natural products. The detailed investigation about anti-trypanosomal activity of new compounds were currently in progress.
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Report
(4 results)
Research Products
(22 results)
