Clinical pharmacological study for proper use in combination with Japanese traditional medicine and Western medicine
| Project/Area Number |
25460116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
坡下 真大 名古屋市立大学, 大学院薬学研究科, 講師 (20613384)
佐藤 浩子 群馬大学, 大学院医学系研究科, 講師 (50396652)
山本 康次郎 群馬大学, 大学院医学系研究科, 教授 (70174787)
手塚 淑人 慶應義塾大学, 薬学部(芝共立), 助教 (00433649)
青森 達 慶應義塾大学, 薬学部(芝共立), 講師 (40620802)
鈴木 小夜 慶應義塾大学, 薬学部(芝共立), 講師 (90424134)
小林 典子 慶應義塾大学, 薬学部(芝共立), 助教 (90245449)
地引 綾 (中島綾) 慶應義塾大学, 薬学部(芝共立), 助教 (00746224)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 東西医薬品の併用 / 漢方薬 / 西洋医薬品 / 有効性・安全性 / 副作用予防 / 漢方薬の臨床薬理 / 大建中湯 / モサプリドクエン酸塩 / カルテ調査 / 胃がん / 大腸がん / ガスモチン / 処方調査 / 疫学研究 / 和漢薬 / オピオイド |
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| Outline of Final Research Achievements |
In collaboration with Department of General Medicine at Gunma University Hospital for the purpose of establishing the evaluation method of efficacy and safety of combination use of Japanese traditional medicines and Western medicines, and verifying combination case of Japanese medicine for avoiding side effects of Western medicines. Then, it was found that after the operation of gastric or colorectal cancer, it was possible to promote gastrointestinal motility, antiemetic effect and etc by using Daikenchuto with mosapride citrate.
In collaboration with the Center for Kampo Medicine, Keio University School of Medicine, the onset of pseudoaldosteronism in licorice and glycyrrhizin preparations is more frequent in patients with high direct-bilirubin (D-Bil) and low albumin values, and the accuracy was higher in high D-Bil values.
In collaboration with the National Cancer Center Hospital East, it was suggested that Shiteito suppressed the anticancer drug-induced serious hiccups .
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Report
(5 results)
Research Products
(25 results)
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[Journal Article] Assessment of DDR2, BRAF, EGFR and KRAS mutations as therapeutic targets in non-adenocarcinoma lung cancer patients.2014
Author(s)
Yashima H, Shimizu K, Araki T, Aomori T, Ohtaki Y, Nagashima T, Enokida Y, Atsumi J, Nakamura T, Takeyoshi I, Yamamoto K.
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Journal Title
Mol Clin Oncol.
Volume: 2
Pages: 714-718
Related Report
Peer Reviewed / Open Access
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[Journal Article] Assessment of DDR2, BRAF, EGFR, and KRAS mutations as therapeutic markers in Japanese non-adenocarcinoma lung cancer patients.2014
Author(s)
Yashima H, Shimizu K, Araki T*, Aomori T, Ohtaki Y, Nagashima T, Enokida Y, Atsumi J, Nakamura T, Takeyoshi I, Yamamoto K
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Journal Title
Mol Clin Oncol
Volume: 印刷中
Related Report
Peer Reviewed
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[Presentation] Effect of genetic polymorphism of azathioprine-metabolizing enzymes on response to rheumatoid arthritis treatment2016
Author(s)
AOMORI Tohru, TSUCHIYA Ayumi, SAKAMOTO Mami, SUZUKI Sayo, JIBIKI Aya, OTSUKA Naoko, ISHIOKA Eriko, KANEKO Yuko, TAKEUCHI Tsutomu, NAKAMURA Tomonori
Organizer
21st Congress of European Association of Hospital Pharmacists
Place of Presentation
Wien, Austria
Year and Date
2016-03-16
Related Report
Int'l Joint Research
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[Presentation] CYP3A4変異型分子種における testosterone 及び midazolam の代謝に対する競合阻害剤の阻害強度の比較2014
Author(s)
小縣淳子, 秋好健志, 今岡鮎子, 日比野英幸, 荒木拓也, 宮崎光江, F,P Guengerich, 中村克徳, 中村智徳, 山本康次郎, 大谷寿一
Organizer
日本薬学会 第134年会
Place of Presentation
熊本大学
Related Report
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[Presentation] 薬局実務実習におけるOTC薬実習の問題点とその改善のための提案.2013
Author(s)
剱田侑希, 今井奈津美, 桑原亜記, 松元美奈子, 吉田 彩, 高木彰紀, 手塚淑人, 小林典子, 青森達, 鈴木小夜, 門田佳子, 大谷壽一, 中村智徳
Organizer
第23回日本医療薬学会年会
Place of Presentation
仙台国際センター
Related Report
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