Utility of herbal medicine for remission maintenance therapy of ulcerative colitis

• Project/Area Number: 25460123
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Natural medicines
• Research Institution: Yamaguchi University
• Principal Investigator: HASHIMOTO Shinichi 山口大学, 医学部附属病院, 講師 (40530217)
• Co-Investigator(Kenkyū-buntansha): 高見 太郎 山口大学, 医学(系)研究科(研究院), 講師 (60511251) ; 山本 直樹 山口大学, 大学教育機構, 准教授 (90448283)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 潰瘍性大腸炎 / 大建中湯 / dextran sulfate sodium / 寛解維持療法

Outline of Final Research Achievements

We evaluated the effects of daikenchuto(DKT) on dextran sulfate sodium- (DSS-) induced ulcerative colitis(UC) mouse model. the colon lengths of DKT group were longer than those of the DSS group. the DKT group maintained significantly higher levels of serum hemoglobin. The DKT group exhibited significantly longer survival time than the DSS group. Our results indicate that DKT prevented inflammation in the colon, indicating its potential as a new therapeutic agent for UC.

Research Products

• [Journal Article] Protective Effect of Daikenchuto on Dextran Sulfate Sodium-Induced Colitis in Mice (2017)
  • Author(s): Takaharu Matsunaga, Shinichi Hashimoto, Naoki Yamamoto, Ryo Kawasato, Tomohiro Shirasawa, Atsushi Goto, Koichi Fujisawa, Taro Takami, Takeshi Okamoto, Jun Nishikawa, and Isao Sakaida
  • Journal Title: Gastroenterology Research and Practice Volume: 1298263 Pages: 1298263-1298263
  • DOI: 10.1155/2017/1298263
  • Peer Reviewed / Open Access / Acknowledgement Compliant