| Project/Area Number |
25460129
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Iwaki Meisei University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TABUCHI Yoshiaki 富山大学, 研究推進機構, 教授 (20322109)
YAMADA Haruki 東京薬科大学, 薬学部, 教授 (60096691)
KAWAGUTI Kiichirou いわき明星大学, 薬学部, 教授 (10146334)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 潰瘍性大腸炎 / 酪酸 / 結腸上皮細胞 / 腸表皮細胞 / 細胞死 / 結腸上皮 |
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| Outline of Final Research Achievements |
Recent findings demonstrated that a significant number of Fusobacterium varium was identified in the mucosa of patients with ulcerative colitis (UC), and it has been suggested that the butyrate produced by F. varium involved in the pathogenesis of UC. In the screening of Sino-Japanese herbal medicines to protect butyrate-induced death of murine colonic epithelial cells MCE301 as an in vitro model of UC, it was found that the extract of Alisma orientale Juzepczuk (Alismataceae) showed potent protective activity against butyrate-induced cell death. Bioassay-guided purification of methanol extract of the rhizome of A. orientale let to the isolation of alosol B and alisol B acetate. These results suggest that the use of alosol B and alisol B acetate, or a crude extract of A. orientale containing these compounds are expected the effectiveness to relieve UC caused by the butyrate-induced death of colonic epithelial cells.
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