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Synthesis and functional research of glycosphingolipids from marine natural products

Research Project

Project/Area Number 25460131
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Natural medicines
Research InstitutionKeio University

Principal Investigator

Hada Noriyasu  慶應義塾大学, 薬学部, 准教授 (70296531)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords糖脂質 / 海綿 / 化学合成 / 生物活性 / ホヤ / カイメン / 海洋天然物 / ヒト乳癌細胞株 / 抗腫瘍
Outline of Final Research Achievements

The oligosaccharide residues of glycoprotein and glycosphingolipids in mammalian tissues have been extensively studied for various biological recognition in recent years. In contrast, much less time has been devoted to structures of oligosaccharides from invertebrates that differ significantly from mammalian glycans. Due to these differences in the glycan structure we have been interested in the relationships between the structure and biological activity of oligosaccharides from invertebrate species, and in our continuing studies to elucidate the mechanism of host-parasite interaction. We carried out the synthesis of oligosaccharides from some Marine sponge and Sea‐squirts, and got target oligosaccharides and elucidated a biological activities.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (21 results)

All 2016 2015 2014 2013

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (13 results)

  • [Journal Article] Synthesis of a new glycosphingolipid, neurosporaside, from Neurospora crassa.2015

    • Author(s)
      I. Ohtsuka, N. Hada, M.Kanemaru, T. Fujii, T. Atsumi, N. Kakiuchi.
    • Journal Title

      Carbohydr. Res.

      Volume: 404 Pages: 9-16

    • DOI

      10.1016/j.carres.2014.11.018

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Model compounds rerated to linear β-D-(1→6)-galactosyl side-chains of polysaccharides from Astragalus mongholicus Bunde.2015

    • Author(s)
      N. Hada, R. Shimura, K. Hakamata, H. Kiyohara, H. Yamada, T. Takeda, F. Kiuchi.
    • Journal Title

      Heteracycles,

      Volume: 90 Issue: 1 Pages: 563-578

    • DOI

      10.3987/com-14-s(k)61

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthetic studies on glycosphingolipids from protostomia phyla: Synthesis of glycosphingolipid from the marine sponge Spheciospongia vesparia and its analogue2014

    • Author(s)
      N. Hada, A. Miyamura, I. Ohtsuka, F. Kiuchi.
    • Journal Title

      Heterocycles

      Volume: 88 Issue: 1 Pages: 689-704

    • DOI

      10.3987/com-13-s(s)23

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] An expeditious route for 2-acetamido-4-O-methyl-2-deoxy-D-mannopyranose from a Ferrier derivative of tri-O-acetyl-D-glucal, which contributes to the synthesis of laninamivir (CS-8958), a neuraminidase inhibitor2013

    • Author(s)
      H. Okazaki, K. Hanaya, M. Shoji, T. Sugai
    • Journal Title

      Tetrahedron

      Volume: 69 Issue: 37 Pages: 7931-7935

    • DOI

      10.1016/j.tet.2013.07.018

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemo-enzymatic transformation of naturally abundant naringin to luteolin, a flavonoid with various biological effects2013

    • Author(s)
      R. Kobayashi, T. Itou, K. Hanaya, M. Shoji, N. Hada, T. Sugai
    • Journal Title

      J. Mol. Catal. B : Enz

      Volume: 92 Pages: 14-18

    • DOI

      10.1016/j.molcatb.2013.03.002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Further structural characterization of Echinococcus granulosus laminated layer carbohydrates: The blood-antigen P1-motif gives rise to branches at different points of the O-glycan chains.2013

    • Author(s)
      Gerardo Lin
    • Journal Title

      Glycobiology

      Volume: 23 Issue: 4 Pages: 438-452

    • DOI

      10.1093/glycob/cws220

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of anti-inflammatory activity of orengedokuto: Importance of combination of flavonoids in inhibition of PGE2 production in mouse macrophage-like cell line J774.12013

    • Author(s)
      N. Oshima, Y. Narukawa, N. Hada and F. Kiuchi.
    • Journal Title

      J. Nat. Med.

      Volume: 67 Issue: 2 Pages: 281-288

    • DOI

      10.1007/s11418-012-0679-2

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis of a New Glycosphingolipid from the Marine Ascidian Microcosmus sulcatus using a One-Pot Glycosylation Strategy2013

    • Author(s)
      Ohtsuka I
    • Journal Title

      Tetrahedron

      Volume: 69 Issue: 5 Pages: 1470-1475

    • DOI

      10.1016/j.tet.2012.12.023

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 光アフィニティーラベル法によるLeX型糖鎖の機能解明を志向した分子ツールの開発2016

    • Author(s)
      大塚功, 定金豊, 羽田紀康, 渥美聡孝, 垣内信子
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] ブラインシュリンプ Artemia franciscana 由来新規糖脂質の合成研究 (3)2016

    • Author(s)
      金谷貴行, 渡邊敏子, 羽田紀康
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 無脊椎動物由来糖脂質の合成研究(56) 海面Agelas Disper由来の糖脂質(2)2016

    • Author(s)
      古沢小波, 木内文之, 羽田紀康
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] エキノコックス Echinococcus granulosus 由来糖タンパク質の糖鎖部分に関する合成研究2015

    • Author(s)
      植田尚, 羽田紀康, 木内文之
    • Organizer
      GlycoTOKYO2015シンポジウム
    • Place of Presentation
      慶應義塾大学理工学部(横浜)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 海面Agelas Disper由来糖脂質の合成研究2015

    • Author(s)
      古沢小波, 木内文之, 羽田紀康
    • Organizer
      GlycoTOKYO2015シンポジウム
    • Place of Presentation
      慶應義塾大学理工学部(横浜)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] エキノコックス Echinococcus multilocularis 由来糖脂質のビオチン誘導体の合成研究2015

    • Author(s)
      北村彩夏, 羽田紀康, 木内文之, 山野公明.
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] マボヤHalocynthia roretzi 由来糖脂質の合成研究2015

    • Author(s)
      金谷貴行, 羽田紀康, 渡邊敏子.
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 子嚢菌Hirsutella rhossiliensis由来糖脂質の合成研究2015

    • Author(s)
      眞塩理帆, 金谷貴行, 羽田紀康, 渡邊敏子
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] ブタ回虫Ascaris suum由来糖脂質非還元末端糖鎖部の合成と、ヒ卜血清に対する抗原性2014

    • Author(s)
      羽田紀康, 梅田悠奈, 木内文之, 山野公明
    • Organizer
      第33回日本糖質学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-08-10 – 2014-08-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Neurospora crassa由来糖脂質Neurosporasideの合成2014

    • Author(s)
      大塚功, 羽田紀康, 金丸美佐紀, 藤井隆成, 渥美聡孝, 垣内信子
    • Organizer
      第33回日本糖質学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-08-10 – 2014-08-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 無脊椎動物由来糖脂質の合成研究(55) 海綿Agelas dispar由来の糖脂質.2014

    • Author(s)
      奥村謙, 羽田紀康, 木内文之.
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 海綿Spheciospongia vesparia 由来糖脂質の合成.2013

    • Author(s)
      宮村知良, 羽田紀康, 大塚功, 木内文之.
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] マボヤ Halocynthia roretzi 由来新規糖脂質の合成.2013

    • Author(s)
      金谷貴行, 羽田紀康, 渡邊敏子.
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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