Development of molecular targeted drugs for oral cancer cell invasion using herbal end products
| Project/Area Number |
25460137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHSHIMA Mitsuhiro 奥羽大学, 薬学部, 教授 (30194145)
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| Co-Investigator(Renkei-kenkyūsha) |
TORIZUKA Kazuo 昭和大学, 薬学部, 教授 (60135035)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 口腔がん浸潤モデル / 三次元培養 / 生薬 / 口腔癌浸潤モデル / 3次元培養 / 浸潤阻害剤 |
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| Outline of Final Research Achievements |
Previously, we have separated periodontitis-associated fibroblasts (PAF) which aggressively degrade collagen when cultured in three dimension (3D) with gingival epithelial cells. Using these fibroblasts, we have established “in vitro oral cancer invasion model” since PAFs strongly induced oral cancer cell invasion. Screening of 60 kinds of herbal end products using this model revealed that Licorice, and others had inhibitory effect for oral cancer cell invasion. Microarray analyses were performed using 3D gels and compared the gene expression profile between initial invasion period and invasion period. The results suggested that several kinds of extracellular matrix protein gene expression was enhanced during oral cancer cell invasion. Therefore, several herbal end products which regulate extracellular matrix protein expression might be effective for inhibiting oral cancer cell invasion.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Fibroblast VEGF-receptor 1 expression as molecular target in periodontitis2016
Author(s)
Ohshima M, Yamaguchi Y, Ambe K, Horie M, Saito A, Nagase T, Nakashima K, Ohki H, Kawai T, Abico Y, Micke P, Kappert K
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Journal Title
J Clin Periondontol
Volume: 43
Issue: S20
Pages: 128-137
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] CAGE revealed novel biomarker of periodontitis - associated fibroblast.2015
Author(s)
Horie M, Yamaguchi Y, Saito A, Nagase T, Itoh M, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest A, The FANTOM consortium, Lizio M, Kondo M, Suzutani T, Micke P, Ohshima M
Organizer
29th IMGC
Place of Presentation
横浜市開港記念会館（神奈川県横浜市）
Year and Date
2015-11-08
Related Report
Int'l Joint Research
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