| Project/Area Number |
25460139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 多環性天然物 / アルカロイド / リモノイド / 脂肪細胞分化抑制作用 / メラニン産生抑制作用 / オートファジー / bisleuconothine A / 9-methoxyellipticine / スクリーニング / Cassiarin A / Ceranicine B / Bisleuconothine A / 抽出物ライブラリー / 機能性分子 / cassiarin / ceramicine |
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| Outline of Final Research Achievements |
During our search for active ingredients from medicinal plants, we have isolated various kinds of polycyclic alkaloids, and terpenoids with various bioactivities as new drug discovery seeds. Chemical modification and SAR studies were conducted by using a tricyclic alkaloid, cassiarin A from Cassia siamea. Ceramicines, a series of limonoids from Chisocheton ceramicus, were evaluated for lipid-droplets accumulation inhibitory and anti-melanin deposition activities and several ceramicines were found to be active.
In our continuous quest to identify novel polycyclic active compounds of plant origin, bisleuconothine A, a novel bisindole alkaloid from Leuconotis griffithii, showed cytostatic activity in several cell lines. The cytostatic activity may be attributed to its induction of autophagosomes formation. Indole alkaloids from Tabernaemontana phymata was identified as active compounds in inhibiting lipid droplets accumulation.
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