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Search on Seeds for Drug Discovery using Polycyclic Natural Products

Research Project

Project/Area Number 25460139
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Natural medicines
Research InstitutionHoshi University

Principal Investigator

Morita Hiroshi  星薬科大学, 薬学部, 教授 (70220069)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords多環性天然物 / アルカロイド / リモノイド / 脂肪細胞分化抑制作用 / メラニン産生抑制作用 / オートファジー / bisleuconothine A / 9-methoxyellipticine / スクリーニング / Cassiarin A / Ceranicine B / Bisleuconothine A / 抽出物ライブラリー / 機能性分子 / cassiarin / ceramicine
Outline of Final Research Achievements

During our search for active ingredients from medicinal plants, we have isolated various kinds of polycyclic alkaloids, and terpenoids with various bioactivities as new drug discovery seeds. Chemical modification and SAR studies were conducted by using a tricyclic alkaloid, cassiarin A from Cassia siamea. Ceramicines, a series of limonoids from Chisocheton ceramicus, were evaluated for lipid-droplets accumulation inhibitory and anti-melanin deposition activities and several ceramicines were found to be active.
In our continuous quest to identify novel polycyclic active compounds of plant origin, bisleuconothine A, a novel bisindole alkaloid from Leuconotis griffithii, showed cytostatic activity in several cell lines. The cytostatic activity may be attributed to its induction of autophagosomes formation. Indole alkaloids from Tabernaemontana phymata was identified as active compounds in inhibiting lipid droplets accumulation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (40 results)

All 2015 2014 2013 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results,  Acknowledgement Compliant: 5 results) Presentation (23 results) Remarks (2 results)

  • [Journal Article] Bisleuconothine A Exclusively Induces Autophagy by Interfering with AKT-mTOR Signaling Pathway2015

    • Author(s)
      Chin Piow Wong, Ari Seki, Kaori Horiguchi, Tomokazu Shoji, Takashi Arai, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Fumiaki Sato and Hiroshi Morita
    • Journal Title

      J. Nat. Prod.

      Volume: 78 Issue: 7 Pages: 1656-1662

    • DOI

      10.1021/acs.jnatprod.5b00258

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ceramicine B, A Limonoid with Anti-Lipid Droplets Accumulation Activity from Chisocheton ceramicus2014

    • Author(s)
      Chin Piow Wong, Toshio Kaneda, A. Hamid A. Hadi, and Hiroshi Morita
    • Journal Title

      J Nat Med.

      Volume: (in press) Issue: 1 Pages: 22-30

    • DOI

      10.1007/s11418-013-0755-2

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Two Novel Tetracycles, Cassibiphenols A and B from the Flowers of Cassia siamea2014

    • Author(s)
      Jun Deguchi, Tadahiro Sasaki, Yusuke Hirasawa, Toshio Kaneda, Idha Kusumawati, Osamu Shirota, and Hiroshi Morita
    • Journal Title

      Tetrahedron Lett.

      Volume: 55 Issue: 7 Pages: 1362-1365

    • DOI

      10.1016/j.tetlet.2014.01.023

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hupermine A, a novel C16N2-type Lycopodium alkaloid from Huperzia phlegmaria2014

    • Author(s)
      Yusuke Hirasawa, Yuri Kato, Chin Piow Wong, Nahoko Uchiyama, Yukihiro Goda, A. Hamid A. Hadi, Hapipah Mohd Ali, and Hiroshi Morita
    • Journal Title

      Tetrahedron Lett.

      Volume: 55 Issue: 11 Pages: 1902-1904

    • DOI

      10.1016/j.tetlet.2014.01.141

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Chrotacumines G - J, chromone alkaloids from Dysoxylum acutangulum with osteoclast differentiation inhibitory activity2014

    • Author(s)
      Hiroshi Morita, Alfarius Eko Nugroho, Yuta Nagakura, Yusuke Hirasawa, Haruka Yoshida, Toshio Kaneda, Osamu Shirota and Intan Safinar Ismail
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 11 Issue: 11 Pages: 2437-2439

    • DOI

      10.1016/j.bmcl.2014.04.020

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dysotriflorins A - M, Triterpenoids from Dysoxylum densiflorum2014

    • Author(s)
      Alfarius E. Nugroho, Takanori Momota, Rio Sugiura, Marina Hanzawa, Erika Yajima, Yuta Nagakura, Naoki Yasuda, Yusuke Hirasawa, Chin Piow Wong, Toshio Kaneda, A. Hamid A. Hadi, Haruhiko Fukaya, Hiroshi Morita,
    • Journal Title

      Tetrahedron

      Volume: 70 Issue: 51 Pages: 9661-9667

    • DOI

      10.1016/j.tet.2014.10.070

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cyclic Diarylheptanoids as inhibitors of NO production from Acer nikoense2013

    • Author(s)
      Jun Deguchi, Yusuke Motegi, Takahiro Hosoya, Hiroshi Morita
    • Journal Title

      J. Nat. Med.

      Volume: 67 Issue: 1 Pages: 234-239

    • DOI

      10.1007/s11418-012-0660-0

    • NAID

      10031131625

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vasorelaxant effect of FR900359 from Ardisia crenata on rat aortic artery2013

    • Author(s)
      Kazumasa Zaima, Jun Deguchi, Yosuke Matsuno, Toshio Kaneda, Yusuke Hirasawa, Hiroshi Morita
    • Journal Title

      J. Nat. Med.

      Volume: 67 Issue: 1 Pages: 196-201

    • DOI

      10.1007/s11418-012-0644-0

    • NAID

      10031131618

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vasorelaxant activity of indole alkaloids from Tabernaemontana dichotoma2013

    • Author(s)
      Kazumasa Zaima, Ikumi Koga, Nobuhide Iwasawa, Takahiro Hosoya, Yusuke Hirasawa, Toshio Kaneda, Intan Safinar Ismail, Nordin Hj Lajis, Hiroshi Morita
    • Journal Title

      J. Nat. Med.

      Volume: 67 Issue: 1 Pages: 9-16

    • DOI

      10.1007/s11418-012-0638-y

    • NAID

      10031131596

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vasorelaxant effects on rat aortic artery by two types of indole alkaloids, naucline and cadamine2013

    • Author(s)
      Mineri Ishizuka, Ikumi Koga, Kazumasa Zaima, Toshio Kaneda, Yusuke Hirasawa, A. Hamid A. Hadi, Hiroshi Morita
    • Journal Title

      J. Nat. Med.

      Volume: 67 Issue: 2 Pages: 399-403

    • DOI

      10.1007/s11418-012-0689-0

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sanjecumins A and B, New Limonoids from Sandoricum koetjape2013

    • Author(s)
      Yuta Nagakura, Alfarius Eko Nugroho, Yusuke Hirasawa, Takahiro Hosoya, Abdul Rahman, Idha Kusumawati, Noor Cholies Zaini, Hiroshi Morita
    • Journal Title

      J. Nat. Med.

      Volume: 67 Issue: 2 Pages: 381-385

    • DOI

      10.1007/s11418-012-0677-4

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ceramicines from Chisocheton ceramicus as lipid-droplets accumulation inhibitors2013

    • Author(s)
      Chin-Piow Wong, Jun Deguchi, Alfarius Eko Nugroho, Toshio Kaneda, A. Hamid. A. Hadi, Hiroshi Morita
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 23 Issue: 6 Pages: 1786-1788

    • DOI

      10.1016/j.bmcl.2013.01.037

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Walsogynes B - G, limonoids from Walsura chrysogyne2013

    • Author(s)
      Alfarius E. Nugroho, Maho Okuda, Yukari Yamamoto, Yusuke Hirasawa, Chin-Piow Wong, Toshio Kaneda, Osamu Shirota, A. Hamid A. Hadi, Hiroshi Morita
    • Journal Title

      Tetrahedron

      Volume: 69 Issue: 20 Pages: 4139-4145

    • DOI

      10.1016/j.tet.2013.02.095

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Huperminone A, a novel C16N-type Lycopodium alkaloid from Huperzia phlegmaria2013

    • Author(s)
      Yusuke Hirasawa, Yuri Kato, Chin Piow Wong, Nahoko Uchiyama, Yukihiro Goda, A. Hamid A. Hadi, Hiroshi Morita
    • Journal Title

      Tetrahedron Lett.

      Volume: 54 Issue: 12 Pages: 1593-1595

    • DOI

      10.1016/j.tetlet.2013.01.048

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Voacalgines A - E, New Indole Alkaloids from Voacanga grandifolia2013

    • Author(s)
      Yusuke Hirasawa, Hiroko Arai, Abdul Rahman, Idha Kusumawati, Noor Cholies Zaini, Osamu Shirota, Hiroshi Morita
    • Journal Title

      Tetrahedron

      Volume: 69 Issue: 51 Pages: 10869-10875

    • DOI

      10.1016/j.tet.2013.10.097

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 2種のヒカゲノカズラ科植物に含まれるアルカロイドの成分研究2015

    • Author(s)
      大塚瑠里,関口尚香,平澤祐介,内山奈穂子,合田幸広,森田博史
    • Organizer
      日本生薬学会第62回年会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] キョウチクトウ科 Tabernaemontana phymataの脂肪滴蓄積抑制活性に関する研究2015

    • Author(s)
      関詩織、橘川侑季、橘将人、池上一平、平澤祐介、金田利夫、森田博史
    • Organizer
      日本生薬学会第62回年会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] キョウチクトウ科Leuconotis griffithiiより単離した新規アルカロイドの構造2015

    • Author(s)
      張 雯佳,Alfarius Eko Nugroho,平澤祐介,内山奈穂子,袴塚高志,金田利夫,森田博史
    • Organizer
      日本生薬学会第62回年会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Ceramicine Bの脂肪細胞分化に対する抑制作用2015

    • Author(s)
      飯塚菜々子、Chin Piow Wong、金田利夫、森田博史
    • Organizer
      日本生薬学会第62回年会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] センダン科Chisocheton ceramicusから単離したceramicine類の構造研究2015

    • Author(s)
      橋本朱世,川口拓也,中川茉莉,Alfarius Eko Nugroho,Chin Piow Wong,平澤祐介,金田利夫,森田博史,A. Hamid A. Hadi
    • Organizer
      日本生薬学会第62回年会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Research on the constituents of Daphne altaica2015

    • Author(s)
      Alfarius Eko Nugroho,Chin-Piow Wong、Janar Jenis, Osamu Shirota, Toshio Kaneda, Hiroshi Morita
    • Organizer
      日本生薬学会第62回年会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Mollugin誘導体の抗炎症作用2015

    • Author(s)
      中嶋祐輝, 金田利夫, 中田麻美, 西野仁美, 出口潤, 平澤祐介, 森田博史, 川崎洋子, 合田幸広
    • Organizer
      日本生薬学会第62回年会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Ceramicine Bのメラニン産生抑制作用2015

    • Author(s)
      飯島千絵、Chin Piow Wong、外園弥生、Alfarius Eko Nugroho、平澤祐介、金田利夫、A.Hamid A.Hadi、森田博史
    • Organizer
      日本生薬学会第62回年会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Anti-Adipogenesis Activity of Ceramicine B2014

    • Author(s)
      Chin Piow Wong,金田利夫,A. Hamid A. Hadi,森田博史
    • Organizer
      日本生薬学会第61回年会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Indole Alkaloids from Tabernaemontana corymbosa2014

    • Author(s)
      Alfarius Eko Nugroho,馬上未帆,金田利夫,森田博史,A. Hamid A. Hadi
    • Organizer
      日本生薬学会第61回年会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Research-status Report
  • [Presentation] センダン科 Walsura chrysogyneより単離した新規テルペノイドの構造研究2014

    • Author(s)
      山本ゆかり,佐藤勇人,Alfarius Eko Nugroho,後藤沙織,奥田真歩, Chin Piow Wong,平澤祐介,金田利夫,森田博史,A. Hamid A. Hadi,代田修
    • Organizer
      日本生薬学会第61回年会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Research-status Report
  • [Presentation] センダン科 Chisocheton ceramicus の成分研究2014

    • Author(s)
      橋本朱世,川口拓也,Alfarius Eko Nugroho,Chin Piow Wong,平澤祐介,金田利夫,森田博史,A. Hamid A. Hadi
    • Organizer
      日本生薬学会第61回年会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Ceramicine Bのメラニン産生抑制作用に関する研究2014

    • Author(s)
      飯島千絵,Chin Piow Wong,外園弥,Alfarius Eko Nugroho,平澤祐介,金田利夫,A. Hamid A. Hadi,森田博史
    • Organizer
      日本生薬学会第61回年会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Structures and Anti-Lipid Droplets Accumulation Activity of Ceramicines from Chisocheton ceramicus2013

    • Author(s)
      Chin Piow Wong,Jun Deguchi,Alfarius Eko Nugroho,Yusuke Hirasawa,Toshio Kaneda, A. Hamid A. Hadi,Hiroshi Morita
    • Organizer
      第55回天然有機化合物討論会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] mollugin誘導体のLPSシグナル抑制作用2013

    • Author(s)
      中嶋祐輝,金田利夫,中田麻美,西野仁美,出口潤,平澤祐介,森田博史,河崎洋子,合川幸広
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] マメ科 Cassia siamea より単離した新規 anhydrobarakol 誘導体の構造研究2013

    • Author(s)
      出口潤,佐々木忠裕,平澤祐介,金田利夫,森田博史
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] センダン科Walsura chrysogyneより単離した新規テルペノイドの構造研究2013

    • Author(s)
      後藤沙織,Alfarius Eko Nugroho1,山本ゆかり,奥田真歩,Wong Chin Piow,平澤祐介,金田利夫,森田博史, A. Hamid. A. Hadi,代田修
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] キョウチクトウ科Tabernaemontana corymbosaのアルカロイドと血管弛緩作用に関する研究2013

    • Author(s)
      馬上未帆,Alfarius Eko Nugroho,田村典子,佐々木忠裕,平澤祐介,金田利夫,森田博史,A. Hamid. A. Hadi
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] Chisocheton ceramicusより単離したceramicine Bの脂肪細胞分化に対する抑制作用2013

    • Author(s)
      菅谷陸統,Chin Piow Wong,金田利夫,森田博史,A. Hamid A. Hadi
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] オトギリソウ科 Calophyllum scriblitifolium より単離したクロマノン類の血管平滑筋弛緩作用2013

    • Author(s)
      佐々木忠裕,Alfarius Eko Nugroho,石塚美練里,光田恵里香,房梁,平澤祐介,金田利夫,森田博史(マラヤ大・理)A. Hamid A. Hadi
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] センダン科Chisocheton ceramicusより単離したceramicine Bのメラニン産生抑制作用に関する研究2013

    • Author(s)
      飯島千絵,Chin Piow Wong,外園弥生,Alfarius Eko Nugroho,平澤祐介,金田利夫,森田博史
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] キョウチクトウ科Voacanga grandifoliaの成分研究2013

    • Author(s)
      平澤 祐介,新井 寛子,Abdul Rahman,Idha Kusumawati,Noor Cholies Zaini,代田 修,森田 博史
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] Structure-Activity Relationship of Ceramicines with Anti-Adipogenesis Activity2013

    • Author(s)
      Chin Piow Wong,出口潤,Alfarius Eko Nugroho,平澤祐介,金田利夫,森田博史,A. Hamid A. Hadi
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Remarks] 星薬科大学生薬学教室

    • URL

      http://polaris.hoshi.ac.jp/kyoshitsu/shouyaku/shouyaku.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 生薬学教室ホームページ

    • URL

      http://polaris.hoshi.ac.jp/kyoshitsu/shouyaku/shouyaku.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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