| Project/Area Number |
25460144
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Seikou 京都薬科大学, 薬学部, 准教授 (20411035)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | グレリン分泌 / シスプラチン誘発食欲不振モデル / 香辛料 / Kaempferia parviflora / メトキシフラボノイド / pentamethylquercetin / ショウキョウ / [10]-gingerol / 食欲シグナル / 健胃 / penthamethoxyquercetin / niazirin / gingerol / ニューロペプチドY / ショウガ科 / [6]-shogaol |
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| Outline of Final Research Achievements |
Effects of spices among the natural medicines, which have been used as stomachic, on cisplatin-induced anorexia mice and rats were examined. As a result, the extract of rhizome of Kaempferia parviflora and its principal constituents, methoxyflavonoids, such as pentamethylquercetin, were found to promote ghrelin secretion using endocrine cells fraction of rat stomach (in vitro), and pentamethylquercetin was effective in the mice and rats. In addition, several constituents with promotion effects on ghrelin secretions in vitro were isolated from spices such as ginger, long pepper, etc.
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