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Development of novel transcription modulators based on de novo design of scaffolds

Research Project

Project/Area Number 25460146
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Drug development chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

Fujii Shinya  東京大学, 分子細胞生物学研究所, 講師 (60389179)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords生物活性化合物 / 転写因子 / ステロイドホルモン / アンドロゲン受容体 / プロゲステロン受容体 / グルココルチコイド受容体 / ケイ素 / 医薬化学 / 核内受容体 / アンドロゲン / プロゲステロン / グルココルチコイド / PPAR / ファーマコフォア / クルクミン / 前立腺癌
Outline of Final Research Achievements

In this research, development of novel biologically active compounds based on de novo design of scaffolds, with focusing on the pharmacophores of biologically active natural products, was investigated. Based on the structures of several natural products including curcumin, various modulators for nuclear receptors such as androgen receptor and progesterone receptor were developed. The developed compounds are versatile lead compounds for drug discovery, and the methodology developed here is also a promising approach for structural development.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (50 results)

All 2016 2015 2014 2013 Other

All Journal Article (21 results) (of which Peer Reviewed: 20 results,  Acknowledgement Compliant: 10 results) Presentation (27 results) (of which Int'l Joint Research: 3 results) Remarks (2 results)

  • [Journal Article] Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T09013172016

    • Author(s)
      Toyama, H.; Sato, S.; Shirakawa, H.; Komai, M.; Hashimoto, Y.; Fujii, S.*
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 26 Pages: 1817-1820

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design and synthesis of silicon-containing fatty acid amide derivatives as novel peroxisome proliferator-activated receptor (PPAR) agonists2015

    • Author(s)
      Daisuke Kajita, Masaharu Nakamura, Yotaro Matsumoto, Minoru Ishikawa, Yuichi Hashimoto and Shinya Fujii
    • Journal Title

      Bioorganic & Medicinal Chemistry Letter

      Volume: 25 Issue: 16 Pages: 3350-3354

    • DOI

      10.1016/j.bmcl.2015.05.045

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design and synthesis of novel ROR inverse agonists based on dibenzosilole scaffolds as a hydrophobic core structure2015

    • Author(s)
      Toyama, H.; Nakamura, M.; Hashimoto, Y.; Fujii, S.*
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 23 Issue: 13 Pages: 2982-2988

    • DOI

      10.1016/j.bmc.2015.05.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Carboxylic derivatives of vitamin K2 inhibit hepatocellular carcinoma cell growth through caspase/transglutaminase-related signaling pathways2015

    • Author(s)
      Qin, X.-Y.; Fujii, S.; Shimizu, A.; Kagechika, H.; Kojima, S.
    • Journal Title

      J. Nutr. Sci. Vitaminol.

      Volume: 61 Pages: 285-290

    • NAID

      130005102615

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Systematic synthesis and anti-inflammatory activity of ω-carboxylated menaquinone derivatives -Investigation on identified and putative vitamin K metabolites-2015

    • Author(s)
      Fujii, S.; Shimizu, A.; Takeda, N.; Oguchi, K.; Katsurai, T.; Shirakawa, H.; Komai, M.; Kagechika, H.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 23 Issue: 10 Pages: 2344-2352

    • DOI

      10.1016/j.bmc.2015.03.070

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design and synthesis of 4-benzyl-1-(2H)-phthalazinone derivatives as novel androgen receptor antagonists2015

    • Author(s)
      Kazumi Inoue, Ko Urushibara, Misae Kanai, Kei Yura, Shinya Fujii, Mari Ishigami-Yuasa, Yuichi Hashimoto, Shuichi Mori, Emiko Kawachi, Mio Matsumura, Tomoya Hirano, Hiroyuki Kagechika, Aya Tanatani
    • Journal Title

      European Journal of Medicinal Chemistry

      Volume: 102 Pages: 310-319

    • DOI

      10.1016/j.ejmech.2015.08.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 新規ファーマコフォアの構築に基づくアンドロゲン受容体パンアンタゴニストの創製2015

    • Author(s)
      藤井晋也,山田歩,森修一,影近弘之
    • Journal Title

      ケミカルバイオロジー

      Volume: 18 Pages: 6-8

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Development of 1,3-diphenyladamantane derivatives as nonsteroidal progesterone receptor antagonists.2015

    • Author(s)
      Mori, S.; Takeuchi, Y.; Tanatani, A.; Kagechika, H.; Fujii, S.
    • Journal Title

      Bioorg. Med. Chem

      Volume: 23 Issue: 4 Pages: 803-809

    • DOI

      10.1016/j.bmc.2014.12.047

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters2014

    • Author(s)
      Kikuchi E, Mori T, Zeniya M, Isobe K, Ishigami-Yuasa M, Fujii S, Kagechika H, Ishihara T, Mizushima T, Sasaki S, Sohara E, Rai T, Uchida S
    • Journal Title

      J Am Soc Nephrol

      Volume: 26 Issue: 7 Pages: 1525-1536

    • DOI

      10.1681/asn.2014060560

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipase-catalyzed asymmetric acylation of boron cluster-containing secondary alcohols.2014

    • Author(s)
      Mori, S.; Takagaki, R.; Fujii, S.; Matsumura, M.; Tanatani, A.; Kagechika, H.
    • Journal Title

      Tetrahedron Asymm.

      Volume: 25 Issue: 23 Pages: 1505-1512

    • DOI

      10.1016/j.tetasy.2014.10.009

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Structural development of p-carborane-based potent non-secosteroidal vitamin D analogs.2014

    • Author(s)
      Fujii, S.; Sekine, R.; Kano, A.; Masuno, H.; Songkram, C.; Kawachi, E.; Hirano, T.; Tanatani, A.; Kagechika, H.
    • Journal Title

      Bioorg. Med. Chem

      Volume: 22 Issue: 21 Pages: 5891-5901

    • DOI

      10.1016/j.bmc.2014.09.020

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of p-carborane-based nonsteroidal progesterone receptor antagonists.2014

    • Author(s)
      Fujii, S.; Nakano, E.; Yanagida, N.; Mori, S.; Masuno, H.; Kagechika, H.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 22 Issue: 19 Pages: 5329-5337

    • DOI

      10.1016/j.bmc.2014.07.049

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design and synthesis of tetraol derivatives of 1,12-dicarba-closo-dodecaborane as non-secosteroidal vitamin D analogs.2014

    • Author(s)
      Fujii, S.; Kano, A.; Masuno, H.; Songkram, C.; Kawachi, E.; Hirano, T.; Tanatani, A.; Kagechika, H
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Issue: 18 Pages: 4515-4519

    • DOI

      10.1016/j.bmcl.2014.07.075

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of nonsteroidal progesterone receptor antagonists based on C,C’-diphenylcarborane scaffold as a hydrophobic pharmacophore.2014

    • Author(s)
      Fujii, S.; Yamada, A.; Nakano, E.; Takeuchi, Y.; Mori, S.; Masuno, H.; Kagechika, H.
    • Journal Title

      Eur. J. Med. Chem.

      Volume: 84 Pages: 264-277

    • DOI

      10.1016/j.ejmech.2014.07.034

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of 2-Thioxoquinazoline-4-one Derivatives as Dual and Selective Inhibitors of Dynamin-Related Protein 1 (Drp1) and Puromycin-Sensitive Aminopeptidase (PSA)2014

    • Author(s)
      Numadate, A.; Mita, Y.; Matsumoto, Y.; Fujii, S.; Hashimoto, Y.
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 62 Issue: 10 Pages: 979-988

    • DOI

      10.1248/cpb.c14-00333

    • NAID

      130004693775

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Structure–Activity Relationship Study of Triazine-Based Inhibitors of the DNA Binding of NF-κB2014

    • Author(s)
      Fujii, S.; Kobayashi, T.; Nakatsu, A.; Miyazawa, H.; Kagechika, H.
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 62 Issue: 7 Pages: 700-708

    • DOI

      10.1248/cpb.c14-00218

    • NAID

      130004053804

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 球状疎水性ファーマコフォアを有する非セコステロイド型VDRリガンドの創製研究2014

    • Author(s)
      藤井晋也,棚谷綾,平野智也,影近弘之
    • Journal Title

      ビタミン

      Volume: 88 Pages: 389-395

    • NAID

      110009843773

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis and structure-activity relationship of p-carborane-based non-secosteroidal vitamin D analogs.2014

    • Author(s)
      Fujii, S.; Kano, A.; Songkram, C.; Masuno, H.; Tao da, Y.; Kawachi, E.; Hirano, T.; Tanatani, A.; Kagechika, H.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 22 Issue: 4 Pages: 1227-1235

    • DOI

      10.1016/j.bmc.2014.01.015

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of 4-(4-benzoylaminophenoxy)phenol derivatives as androgen receptor antagonists.2013

    • Author(s)
      Yamada, A.; Fujii, S.; Mori, S.; Kagechika, H.
    • Journal Title

      ACS Med. Chem. Lett.

      Volume: 4 Issue: 10 Pages: 937-941

    • DOI

      10.1021/ml4001744

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Copper-mediated C-C Cross-Coupling Reaction of Monocarba-closo-dodecaborate Anion for Construction of Functional Molecules2013

    • Author(s)
      Junichiro Kanazawa, Ryo Takita, Aleksandra Jankowiak, Shinya Fujii, Hiroyuki Kagechika, Daisuke Hashizume, Koichi Shudo, Piotr Kaszynski, and Masanobu Uchiyama
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 52 Issue: 31 Pages: 8017-8021

    • DOI

      10.1002/anie.201302448

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.2013

    • Author(s)
      Mori, T.; Kikuchi, E.; Watanabe, Y.; Fujii, S.; Ishigami-Yuasa, M.; Kagechika, H.; Sohara, E.; Rai, T.; Sasaki, S.; Uchida, S.
    • Journal Title

      Biochem. J.

      Volume: 455 Issue: 3 Pages: 339-345

    • DOI

      10.1042/bj20130597

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] AF-1領域による機能制御を指向した新規アンドロゲン受容体モジュレーターの創製2016

    • Author(s)
      沼館慧剛,谷内出友美,梅田香織,槇島誠,橋本祐一,藤井晋也
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 核内受容体リガンドを指向した1,3,5-トリアジン誘導体の設計と構造展開2016

    • Author(s)
      海東和麻,谷内出友美,中津亜紀,森修一,橋本祐一,影近弘之,藤井晋也
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of nuclear receptor ligands based on the novel hydrophobic pharmacophore2016

    • Author(s)
      Shinya Fujii
    • Organizer
      Advances in Retinoids research.
    • Place of Presentation
      Strasbourg, France
    • Year and Date
      2016-01-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of novel nuclear receptor modulators based on silyl functionality as hydrophobic core structure2015

    • Author(s)
      Fujii, S.; Miyajima, Y.; Toyama, H.; Kajita, D.; Nakamura, M.; Kagechika, H.; Hashimoto, Y.
    • Organizer
      ASMC2015
    • Place of Presentation
      Rehovot, Israel
    • Year and Date
      2015-11-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of androgen receptor (AR) activation function-1 (AF-1) modulators2015

    • Author(s)
      Fujii, S.; Numadate, A.; Noguchi-Yachide, T.; Endo-Umeda, K.; Makishima, M.; Hashimoto, Y.
    • Organizer
      3rd International Conference on Retinoids.
    • Place of Presentation
      岐阜グランドホテル(岐阜県・岐阜市)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 三次元分子構築と元素化学的アプローチを基盤とした疎水性ファーマコフォアの開発2015

    • Author(s)
      藤井晋也
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      日本大学薬学部(千葉県・船橋市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規疎水性ファーマコフォアを有するビタミンD受容体リガンドの創製2015

    • Author(s)
      藤井晋也,平野智也,棚谷綾,影近弘之
    • Organizer
      第1回Neo Vitamin D Workshop学術集会
    • Place of Presentation
      大津プリンスホテル(滋賀県・大津市)
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] アンドロゲン受容体AF-1モジュレーターの創製2015

    • Author(s)
      沼館慧剛,谷内出友美,梅田香織,槇島誠,橋本祐一,藤井晋也
    • Organizer
      日本ケミカルバイオロジー学会第10回年会
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 含ケイ素複素環を骨格構造とする新規ROR転写抑制リガンドの創製2015

    • Author(s)
      外山大純,中村雅陽,橋本祐一,藤井晋也
    • Organizer
      日本ケミカルバイオロジー学会第10回年会
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] メナキノン酸化誘導体の系統的合成と抗炎症作用2015

    • Author(s)
      藤井晋也,清水章貴,小口一起,桂井朋子,白川仁,駒井三千夫,影近弘之
    • Organizer
      日本ビタミン学会第67回大会
    • Place of Presentation
      奈良県新公会堂(奈良県・奈良市)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] ケイ素とcisオレフィンの可換性に着目した含ケイ素PPARアゴニストの創製2015

    • Author(s)
      梶田大資、中村雅陽、松本洋太郎、石川稔、橋本祐一、藤井晋也
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸(兵庫)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] ステロイド代替骨格としてのジフェニルメタン骨格―胆汁鬱滞性疾患治療薬への 展開―2015

    • Author(s)
      小針孝夫、細田信之助、貝沼雅彦、三澤隆、藤井晋也、橋本祐一
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸(兵庫)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 核内受容体選択的なCoactivator Binding Inhibitorの創製研究2015

    • Author(s)
      福田寛充、槇島誠、石川稔、藤井晋也、橋本祐一
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸(兵庫)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] カルボラン含有プロゲステロン受容体リガンドのリパーゼによる光学分割2015

    • Author(s)
      森修一、高垣亮平、藤井晋也、松村実生、棚谷綾、影近弘之
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸(兵庫)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of Transcriptional Modulators Using Three Dimensional Architectures2014

    • Author(s)
      Shinya Fujii, Yasuyuki Endo, Hiroyuki Kagechika, Yuichi Hashimoto
    • Organizer
      ICCEOCA-9_ACP2014
    • Place of Presentation
      クアラルンプール(マレーシア)
    • Year and Date
      2014-12-01 – 2014-12-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Synthesis and characterization of novel m-carborane-containing porphyrinoid2014

    • Author(s)
      Shinya Fujii, Shotaro Iihama, Hiroyuki Kagechika
    • Organizer
      IMEBORON 15
    • Place of Presentation
      プラハ工科大学(チェコ)
    • Year and Date
      2014-08-24 – 2014-08-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Design and synthesis of C,C'-diphenylcarborane derivatives as novel progesterone receptor antagonists2014

    • Author(s)
      Hiroyuki Kagechika, Shuichi Mori, Eiichi Nakano, Ayumi Yamada, Yuki Takeuchi, Hiroyuki Masuno, Shinya Fujii
    • Organizer
      IMEBORON 15
    • Place of Presentation
      プラハ工科大学(チェコ)
    • Year and Date
      2014-08-24 – 2014-08-28
    • Related Report
      2014 Research-status Report
  • [Presentation] カルボランを基盤とする非セコステロイド型VDRリガンドの疎水性部位の構造展開2014

    • Author(s)
      藤井晋也、八田健司、増野弘幸、河内恵美子、影近弘之
    • Organizer
      日本ビタミン学会第66回大会
    • Place of Presentation
      姫路商工会議所(兵庫)
    • Year and Date
      2014-06-13 – 2014-06-14
    • Related Report
      2014 Research-status Report
  • [Presentation] クルクミン誘導体の構造展開による新規PRアンタゴニストの創製2014

    • Author(s)
      藤井晋也、山田歩、森修一、影近弘之
    • Organizer
      日本ケミカルバイオロジー学会第9会年会
    • Place of Presentation
      大阪大学(大阪)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] カルボランを基盤とした新規ビタミンD誘導体の創製2014

    • Author(s)
      八田健司,河内恵美子,増野弘幸,藤井晋也,影近弘之
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市
    • Related Report
      2013 Research-status Report
  • [Presentation] クマリン骨格を基盤とした新規アンドロゲン受容体アンタゴニストの創製2014

    • Author(s)
      古賀瞳,木下満里絵,藤井晋也,影近弘之,棚谷綾
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市
    • Related Report
      2013 Research-status Report
  • [Presentation] Increased hydrophobicity and estrogenic activity of silicon- and germanium-containing phenols2013

    • Author(s)
      Fujii, S.; Miyajima, Y.; Masuno, H.; Kagechika, H.
    • Organizer
      14th Tetrahedron Symposium
    • Place of Presentation
      ウィーン、オーストリア
    • Related Report
      2013 Research-status Report
  • [Presentation] Synthesis and characterization of a conjugated macrocyclic compound containing a carborane cage2013

    • Author(s)
      Iihama, S.; Fujii, S.; Kagechika, H.
    • Organizer
      14th Tetrahedron Symposium
    • Place of Presentation
      ウィーン、オーストリア
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of novel estrogen receptor agonists based on silicon- and germanium-containing hydrophobic functionalities2013

    • Author(s)
      Masuno, H.; Miyajima, Y.; Fujii, S.; Kagechika, H.
    • Organizer
      The 2st HD Physiology International Symposium
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 球状疎水性ファーマコフォアを有する非セコステロイド型VDRリガンドの構造活性相関2013

    • Author(s)
      藤井晋也,Angsuma Wongmayura,増野弘幸,伊藤茂,加納敦,河内恵美子,棚谷綾,影近弘之
    • Organizer
      日本ビタミン学会第65回大会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 新規ファーマコフォアの構築に基づくアンドロゲン受容体パンアンタゴニストの創製2013

    • Author(s)
      藤井晋也,山田歩,森修一,影近弘之
    • Organizer
      日本ケミカルバイオロジー学会第8回年会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] クルクミンの構造要素を基盤とした新規ARアンタゴニストの創製2013

    • Author(s)
      藤井晋也,山田歩,森修一,影近弘之
    • Organizer
      第24回日本レチノイド研究会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Remarks] 東京大学分子細胞生物学研究所生体有機化学研究分野HP

    • URL

      http://www.iam.u-tokyo.ac.jp/chem/IMCB-8ken-HP/Index.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 東京医科歯科大学生体材料工学研究所薬化学分野HP

    • URL

      http://www.tmd.ac.jp/mri/omc/index1.html

    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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