Development of artificial EGF receptor-ligand system based on coiled-coil peptides to manipulate cell functions
| Project/Area Number |
25460148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
Nakase Ikuhiko 大阪府立大学, 21世紀科学研究機構, 講師 (40432322)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 人工受容体 / 細胞機能制御 / ヘリックス相互作用 / ペプチド認識 / ロイシンジッパーペプチド / アクチン骨格 / シグナル伝達 / EGF受容体 / コイルドコイル / 二量体化 |
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| Outline of Final Research Achievements |
To develop artificial receptor-ligand system by usage of artificial coiled-coil peptides to induce receptor dimerization and activation is purpose of research. In this research, artificial epidermal growth factor receptor-ligand system as a model was created to control receptor-based cellular functions. As results, helix peptide ligands effectively activate the artificial receptor on cellular membranes, and the peptide ligand-modified cellular vesicles that can also activate the objective receptor could be successfully developed.
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Report
(4 results)
Research Products
(28 results)
