| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
To develop artificial receptor-ligand system by usage of artificial coiled-coil peptides to induce receptor dimerization and activation is purpose of research. In this research, artificial epidermal growth factor receptor-ligand system as a model was created to control receptor-based cellular functions. As results, helix peptide ligands effectively activate the artificial receptor on cellular membranes, and the peptide ligand-modified cellular vesicles that can also activate the objective receptor could be successfully developed.
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