Research on IDO inhibitor as anticancer agent
| Project/Area Number |
25460149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Kogakuin University (2015)
Okayama University (2013-2014) |
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Principal Investigator |
MATSUNO KENJI 工学院大学, 先進工学部, 教授 (50433214)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | リード化合物 / 抗がん剤 / がん免疫療法剤 / IDO / 免疫寛容 / 構造活性相関 / 創薬 / 阻害剤 / in vivo活性 / 活性増強 / 新規ケモタイプ / 評価系構築 |
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| Outline of Final Research Achievements |
The design, synthesis and biological evaluations for our original IDO inhibitors were conducted. We succeeded enhancement of IDO enzyme inhibition, as well as cellular IDO inhibition. As the result of our efforts, many potent analogues were identified. Furthermore, all potent IDO inhibitors demonstrated in vivo efficacy. The activity would be attributed to IDO inhibition since inactive IDO inhibitor did NOT show the in vivo activity.
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Report
(4 results)
Research Products
(5 results)
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[Presentation] BENZIMIDAZOLE ANALOGUES AS KYNURENINE PRODUCTION INHIBITOR WITHOUT INDOLEAMINE 2,3-DIOXYGENASE INHIBITION2016
Author(s)
Fukuda, M.; Suzuki, K.; Sasaki, T.; Miyachi, H.; Waki, M.; Asai, A.; Hashimoto, T.; Ohno, O.; Takikawa, O.; Matsuno, K.
Organizer
XXIV EFMC International Symposium on Medicinal Chemistry
Place of Presentation
Manchester, UK
Year and Date
2016-08-28
Related Report
Int'l Joint Research
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