| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The design, synthesis and biological evaluations for our original IDO inhibitors were conducted. We succeeded enhancement of IDO enzyme inhibition, as well as cellular IDO inhibition. As the result of our efforts, many potent analogues were identified. Furthermore, all potent IDO inhibitors demonstrated in vivo efficacy. The activity would be attributed to IDO inhibition since inactive IDO inhibitor did NOT show the in vivo activity.
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