| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we focused on retinoid as a compound to promote the anti-inflammatory, anti-oxidative, and phagocytic activities of type 2 microglia. Oral co-administration of Am80 (0.5 mg/kg) and HX630 (5 mg/kg) for 17 days significantly improved memory deficits (Morris water maze) in 8.5-month old APP23 mice. A heptapeptide Sx markedly induced the expression of heme oxygenase-1 in mouse microglia. The antigen molecule for 9F5, a monoclonal antibody that recognizes inflammatory type (type 1) of rat microglia, was identified, and the GFP knock-in mouse was also developed.
|
