Utilization of anti-inflammatory/anti-oxidative/phagocytic activities by type 2 microglia for an Alzheimer's disease therapy
Project/Area Number |
25460150
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Drug development chemistry
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Research Institution | Nigata University of Phermacy and Applied Life Sciences (2014-2015) Kumamoto University (2013) |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | アルツハイマー病 / 記憶改善 / ミクログリア / レチノイド / Am80 / HX630 / ペプチド / 9F5 / 1型ミクログリア / モノクローナル抗体 / 9F5抗原 / furin-like protease / IL-12 / ノックアウトマウス / アルツハイマー病モデルマウス / てんかん / インターロイキン4 / レチノイン酸受容体 / レチノイドX受容体 / オリゴマー状アミロイドβ |
Outline of Final Research Achievements |
In this study, we focused on retinoid as a compound to promote the anti-inflammatory, anti-oxidative, and phagocytic activities of type 2 microglia. Oral co-administration of Am80 (0.5 mg/kg) and HX630 (5 mg/kg) for 17 days significantly improved memory deficits (Morris water maze) in 8.5-month old APP23 mice. A heptapeptide Sx markedly induced the expression of heme oxygenase-1 in mouse microglia. The antigen molecule for 9F5, a monoclonal antibody that recognizes inflammatory type (type 1) of rat microglia, was identified, and the GFP knock-in mouse was also developed.
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Report
(4 results)
Research Products
(14 results)
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[Presentation] アルツハイマー病モデルマウスにおけるレチノイン酸受容体アゴニストAm80とレチノイドX受容体アゴニストHX630の協調的な治療効果2015
Author(s)
川原浩一, 末延道太, 大塚英起, 國安明彦, 杉本幸彦, 前田武彦, 中込まどか, 深澤弘志, 首藤紘一, 中山 仁
Organizer
日本薬学会第135年会
Place of Presentation
デザイン・クリエイティブセンター神戸, 神戸市
Year and Date
2015-03-28
Related Report
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[Presentation] インターロイキン4/インターロイキン13の脳内微量注入は抗炎症性M2様ミクログリアを活性化しアルツハイマー病モデルマウスの空間認知障害を改善する2013
Author(s)
川原浩一, 末延道太, 吉田陽, 古賀清弘, 兵藤敦, 大塚英起, 國安明彦, 玉巻伸章, 杉本幸彦, 中山 仁
Organizer
Neuro2013
Place of Presentation
京都国際会議場, 京都市
Related Report
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