Novel therapeutic strategy for intractable inflammatory disease targeting PKCeta
| Project/Area Number |
25460153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Showa University |
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Principal Investigator |
Ohba Motoi 昭和大学, 腫瘍分子生物学研究所, 講師 (70297018)
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| Co-Investigator(Renkei-kenkyūsha) |
Shibanuma Motoko 昭和大学, 薬学部, 教授 (60245876)
Kohno Yohko 昭和大学, 歯学部, 准教授 (40195681)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 分子標的治療 / 炎症 / PKC / 炎症性疾患 / 皮膚 / 分子標的薬 |
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| Outline of Final Research Achievements |
Our goal is to develop novel therapeutic methods for severe inflammatory diseases such as atopic dermatitis (AD) and arteriosclerosis targeting PKCeta. We assessed the effects of siRNA and pseudosubstrate peptide for PKCeta on AD-like dermatitis in Nc/Nga mice, model for AD. Administration of PKCeta siRNA using some transdermal delivery systems suppressed deterioration of dermatitis including itching or fissure on the back skin and ear. Moreover, novel siRNA sequences for PKCeta inhibiting its expression significantly were identified. Furthermore, we examined the effects of PKCeta gene knockout in arteriosclerosis model mice; ApoE by ApoE/PKCeta double knockout mice.
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Report
(5 results)
Research Products
(16 results)
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[Journal Article] The acquired resistant mechanisms for sequential treatment of EGFR-TKI to Met-TKI/EGFR-TKI in a Met amplified EGFR-TKI resistant lung adenocarcinoma cells, harboring EGFR activating mutation.2016
Author(s)
64.Yamaoka T., Ohmori T., Ohba M., Arata S., Kishino Y., Murata Y., Kusumoto S., Ishida H., Shirai T., Hirose T., Ohnishi T., and Sasaki Y.
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Journal Title
Mol. Cancer Ther.
Volume: 15
Issue: 12
Pages: 3040-3054
DOI
Related Report
Peer Reviewed
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[Journal Article] Silver Nanoscale Hexagonal Column Chips for Detecting Cell-Free DNA and Circulating Nucleosomes in Cancer Patients2015
Author(s)
H. Ito, K. Hasegawa, Y. Hasegawa, T. Nishimaki, K. Hosomichi, S. Kimura, M. Ooba, H. Yao, M. Onimaru, I. Inoue, H. Inoue
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 10455-10455
DOI
Related Report
Peer Reviewed / Open Access
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