Creation of novel anticancer lead compounds targeting receptor-type tyrosine kinase Met molecule
Project/Area Number |
25460156
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Drug development chemistry
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Research Institution | Tokyo University of Science |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TAKASAWA Ryoko 東京理科大学, 薬学部・薬学科, 講師 (10398828)
藤川 誠 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (90573048)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 医薬分子設計 / 癌 / Met / チロシンキナーゼ阻害剤 / in silico分子設計 / ペプチド / アロステリック部位 / アポトーシス / チロシンキナーゼ / キナーゼ阻害剤 / in cilico分子設計 |
Outline of Final Research Achievements |
The receptor-type tyrosine kinase Met, which is known to involved in the many steps of cancer growth and development, is an attractive molecular target for the creation of new anticancer drugs. In this study, we attempted to create new small molecular inhibitors through the most optimized-binding peptide as a design-chip, which is designed by using inactive form of Met. Interestingly, we could discover novel inhibitors, which bind to the allosteric site of Met molecule.
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Report
(4 results)
Research Products
(113 results)
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[Journal Article] MicroRNA-351 regulates two-types of cell death, necrosis and apoptosis, induced by 5-fluoro-2’-deoxyuridine2016
Author(s)
Sato A., Omi T., Yamamoto A., Satake A., Hiramoto A., Masutani M., Tanuma S., Wataya Y., Kim H.-S.
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Journal Title
PLOS ONE
Volume: 11
Issue: 4
Pages: e0153130-e0153130
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells2015
Author(s)
Sakagami H., Shimada C., Kanda Y., Amano O., Sugimoto M., Ota S., Soga T., Tomita M., Sato A., Tanuma S., Takao K., Sugita Y.
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Journal Title
Toxicology Reports
Volume: 2
Pages: 1281-1290
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death.2015
Author(s)
Toki Y, Takenouchi T, Harada H, Tanuma S, Kitani H, Kojima S, Tsukimoto M.
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 458(4)
Issue: 4
Pages: 771-776
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A gain-of-function screen to identify genes that reduce lifespan in the adult of Drosophila melanogaster.2014
Author(s)
Nakayama M, Ishibashi T, Ishikawa HO, Sato H, Usui T, Okuda T, Yashiro H, Ishikawa H, Taikou Y, Minami A, Kato K, Taki M, Aigaki T, Gunji W, Ohtsu M, Murakami Y, Tanuma S, Tsuboi A, Adachi M, Kuroda J, Sasamura T, Yamakawa T, Matsuno K,
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Journal Title
BMC Genet.
Volume: 16
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Atypical protein kinase C (aPKC) 依存的なALDH1 陽性乳癌幹細胞の生存メカニズムの解析2016
Author(s)
野崎 優香, 稲田 将大, 片山 鈴花, 中根 裕美, 二俣 沙央里, 小野寺 佑佳,原 泰志, 安部 良, 今井 美沙, 田沼 靖一, 秋本 和憲
Organizer
日本薬学会第136年会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-03-26
Related Report
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[Presentation] 乳癌ALDH1 陽性癌幹細胞におけるatypical protein kinase C 依存的な解糖系代謝制御機構の役割2016
Author(s)
片山 鈴花, 野崎 優香, 中根 裕美, 稲田 将大, 小野寺 佑佳, 神保 美穂, 原 泰志,今井 美沙, 安部 良, 田沼 靖一, 大野 茂男, 川上 隆雄, 秋本 和憲
Organizer
日本薬学会第136年会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-03-26
Related Report
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[Presentation] ヒト乳癌におけるAtypical protein kinase C (aPKC)λ/ι と糖代謝機構との関連2016
Author(s)
本村 瞳, 片山 鈴花, 多森 翔馬, 松村 将史, 柳川 拓哉, 和氣 由布子,高澤 涼子, 田沼 靖一, 宮城 洋平, 長嶋 洋治, 今井 美沙, 佐藤 圭子,秋本 和憲
Organizer
日本薬学会第136年会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-03-26
Related Report
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[Presentation] カカオ成分のアポトーシス制御2014
Author(s)
田沼靖一
Organizer
第19回チョコレート・ココア国際栄養シンポジウム
Place of Presentation
経団連会館(東京都・千代田区)
Year and Date
2014-09-19
Related Report
Invited
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[Book] ニュートン別冊 やさしくわかる 生命の科学2014
Author(s)
田沼靖一,有田隆也,池原健二,石井哲也,井田 茂,上田泰己,木賀大介,倉本 圭,五條堀 孝,小林憲正,西條政幸,斎藤成也,菅 裕明,高畑尚之,瀧ノ上正浩,田端和仁,出口 茂,長沼 毅,藤井紀子,ポール・デイヴィス,松井孝典,松岡雅雄,山内一也,吉川研一,リチャード・ドーキンス
Total Pages
160
Publisher
ニュートンプレス
Related Report
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