Development of a peptidic HSP47 inhibitor as an antifibrotic agent
| Project/Area Number |
25460158
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Waseda University |
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Principal Investigator |
Koide Takaki 早稲田大学, 理工学術院, 教授 (70322253)
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| Co-Investigator(Renkei-kenkyūsha) |
MASUDA Ryo 早稲田大学, 理工学術院, 助教 (90632159)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ペプチド / コラーゲン / 分子シャペロン |
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| Outline of Final Research Achievements |
HSP47, an endoplasmic reticulum (ER)-resident collagen-specific molecular chaperone, contributes to the overproduction of collagen in fibrotic diseases. The aim of this study was to deliver an HSP47 inhibitor peptide to the ER via the retrograde vesicular transport system. The result demonstrated that the peptide was efficiently taken up by the cell in vitro. However, accumulation of the peptides to the ER lumen has not been achieved.
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Report
(4 results)
Research Products
(5 results)
