| Project/Area Number |
25460164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
TSUDA YUKO 神戸学院大学, 薬学部, 教授 (10098478)
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| Co-Investigator(Kenkyū-buntansha) |
HIDAKA KOUSHI 神戸学院大学, 薬学部, 講師 (30445960)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | プラスミン / 阻害剤 / 活性部位指向型 / 炎症性疾患治療薬 / P1’ 残基 / P2残基 / 酵素選択性 |
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| Outline of Final Research Achievements |
Plasmin (PL) plays a dominant role in the fibrinolysis pathway so that PL inhibitors have been used as a hemostatic agent. Additionally, PL is activated in specific regions of the extracellular milieu to digest many proteins on the localized cell surface resulting in inducing cell inversion and metastasis and alternating the expression of cytokines. In this work, we disclosed 1) PL inhibitor (YO-2) attenuated both aGVHD- and colitis-associated lethality in mice; 2) more potent and selective PL inhibitor was obtained.
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