Cleavage of sulfated glycan as a regulatory event for inflammatory responses to infection and chemical compounds
| Project/Area Number |
25460165
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Hoshi University (2016)
The University of Tokyo (2013-2015) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 環境系薬学 / 感染 / 炎症 / 好中球 / マスト細胞 / 細胞外マトリックス / ヘパラナーゼ / ケモカイン / 微生物・感染症学 / アレルギー / 敗血症 / 上皮細胞 / マトリックスメタロプロテアーゼ / 脱顆粒 |
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| Outline of Final Research Achievements |
Acute inflammation as a cause of infection occasionally expands to whole body, which gives rise to fatal systemic infection. Apart from previous approaches focusing on identification of critical mediators, our focus is on microenvironments that help a variety of mediators’ action, also degrading process of extracellular matrices. Heparanase is an enzyme involved in basement membrane degradation as well as enhanced release of inflammatory mediators resulting from cleavage of heparan sulfate. Our goal is to elucidate how inflammatory reaction is regulated by cleavage of sulfated carbohydrates, also to suppress inflammation through inhibition of heparanase activity. We examined a novel regulatory mechanism of inflammation of via cleavage of heparin sulfate/heparin, therapeutic effect of a heparanase inhibitor on inflammatory diseases, and a novel proinflammatory cytokine-like action of heparanase.
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Report
(5 results)
Research Products
(26 results)
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[Journal Article] POMGNT1 Is Glycosylated by Mucin-Type <i>O</i>-Glycans2015
Author(s)
Xin X, Akasaka-Manya K, Manya H, Furukawa J, Kuwahara N, Okada K, Tsumoto H, Higashi N, Kato R, Shinohara Y, Irimura T, Endo T.
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 38
Issue: 9
Pages: 1389-1394
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mast cells from extracellular matrices.2014
Author(s)
Higashi N, Waki M, Sue M, Kogane Y, Shida H, Tsunekawa N, Hasan A, Sato T, Kitahara A, Kasaoka T, Hayakawa Y, Nakajima M, Irimura T.
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Journal Title
Biochemical Jornal
Volume: 458(2)
Issue: 2
Pages: 291-9
DOI
Related Report
Peer Reviewed
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