Estimation of fetotoxicity of chemical compounds with human fetal liver cells and molecular basis of their toxicities
| Project/Area Number |
25460167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Shinshu University |
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Principal Investigator |
YAMAORI Satoshi 信州大学, 学術研究院医学系(医学部附属病院), 准教授 (40360218)
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| Co-Investigator(Kenkyū-buntansha) |
OHMORI Shigeru 信州大学, 学術研究院医学系(医学部附属病院), 教授 (70169069)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ヒト胎児肝細胞 / 胎児毒性 / 薬物代謝酵素 / 発現解析 |
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| Outline of Final Research Achievements |
Fetotoxicity of chemical compounds was investigated with human fetal liver cells. Among the chemical compounds examined, tamoxifen, diclofenac, and retinoic acid induced strong cytotoxicity, from which glutathione S-transferase did not protect human fetal liver cells. A lot of test compounds induced the expression of drug-metabolizing enzymes such as cytochrome P450s and sulfotransferases in human fetal liver cells.
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Report
(4 results)
Research Products
(10 results)
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[Presentation] Inducibility of CYP enzymes by cannabidiol2015
Author(s)
Watanabe K, Yamaori S, Jiang R, Kinugasa Y, Okushima Y, Yamamoto I
Organizer
25th Annual Symposium of the International Cannabinoid Research Society
Place of Presentation
Wolfville (Canada)
Year and Date
2015-06-29
Related Report
Int'l Joint Research
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