Analysis of cytotoxicity to host cells of live bacilli among Mycobacterium species
| Project/Area Number |
25460170
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
Takii Takemasa 名古屋市立大学, 薬学研究科(研究院), 准教授 (80244573)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 感染症 / 結核菌 / 細胞傷害性 / サイトカイン / 抗酸化活性 / 細胞傷害活性 / インターロイキン / 腫瘍壊死因子 / 病原性 / 核酸 / ブースターワクチン / インターロイキン１ / 老化 |
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| Outline of Final Research Achievements |
We have previously reported that virulent Mycobacteria exhibit strong cytotoxicity to host cells (JICR, 2001). Supported by this research fund, we revealed that the anti-oxidative activity of those bacilli would relate to the long time survival in the host cells and the strong activity of cytokines production from infected host cells (Kekkaku, 2015, Microbiol Immunol., 2015). So, we expected that the anti-oxidative activity of the bacilli would relate to the cytotoxicity to the host cells.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Reactivation of immune responses against Mycobacterium tuberculosis by boosting with the CpG oligomer in aged mice primarily vaccinated with Mycobacterium bovis BCG2013
Author(s)
Taniguchi K, Takii T, Yamamoto S, Maeyama J, Iho S, Maruyama M, Iizuka N, Ozeki Y, Matsumoto S, Hasegawa T, Miyatake Y, Itoh S, Onozaki K.
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Journal Title
Immun Ageing
Volume: 10
Issue: 1
Pages: 25-25
DOI
Related Report
Peer Reviewed
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[Presentation] A Contribution of arginine deiminase pathway to the acid tolerance response in Mycobacterium avium sub-strains avium and hominissuis2016
Author(s)
Takemasa Takii, Tetsuya Yagi, Kenji Ogawa, Shinji Maeda, Kei Nishimori, Nagatoshi Fujiwara, Yoshitaka Goto, Toshio Yamazaki, Naoya Ohara, and Kikuo Onozaki
Organizer
The U.S.–Japan Cooperative Medical Sciences Program presents 50th Anniversary Celebration 18th International Conference on Emerging Infectious Diseases (EID)
Place of Presentation
Washington DC, USA
Year and Date
2016-01-11
Related Report
Int'l Joint Research
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[Presentation] Boosting effect of Oligo-B in super aged mice primarily vaccinated with Mycobacterium bovis BCG on the protection activity against Mycobacterium tuberculosis infection
Author(s)
Takemasa Takii, Keiichi Taniguchi, Saburo Yamamoto, Jun-ichi Maeyama, Sumiko Iho, Mitsuo Maruyama, Narushi Iizuka, Yuriko Ozeki, Sohkichi Matsumoto, Saotomo Itoh and Kikuo Onozaki
Organizer
Front Range Mycobacteria Conference
Place of Presentation
Fort Collins, CO, USA
Related Report
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