Application of Staphylococcual immune disturbing toxins, SSLs to development of newly drugs and treatments.
| Project/Area Number |
25460171
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
Itoh Saotomo 名古屋市立大学, 薬学研究科(研究院), 講師 (70308013)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 細菌毒素 / 免疫回避 / 黄色ブドウ球菌毒素 / スーパー抗原様毒素 |
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| Outline of Final Research Achievements |
Staphylococcal superantigen-like proteins(SSL) recognize and disturb various host immune molecules, and involved in immune evasion of the bacteria. In this study, we analayzed molecular mechanisms of binding SSLs to host target molecules.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Reactivation of immune responses against Mycobacterium tuberculosis by boosting with the CpG oligomer in aged mice primarily vaccinated with Mycobacterium bovis BCG2013
Author(s)
Taniguchi K, Takii T, Yamamoto S, Maeyama J, Iho S, Maruyama M, Iizuka N, Ozeki Y, Matsumoto S, Hasegawa T, Miyatake Y, Itoh S, Onozaki K.
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Journal Title
Immun Ageing
Volume: 10
Issue: 1
Pages: 25-25
DOI
Related Report
Peer Reviewed
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[Journal Article] Cigarette smoke condensate extracts induce IL-1 beta production from rheumatoid arthritis patient-derived synoviocytes, but not osteoarthritis patient-derived synoviocytes, through aryl hydrocarbon receptor-dependent NF-kappa B activation and novel NF-kappa B sites.2013
Author(s)
Adachi M, Okamoto S, Chujyo S, Arakawa T, Yokoyama M, Yamada K, Hayashi A, Akita K, Takeno M, Ito S, Takii T, Waguri-Nagaya Y, Otsuka T, Hayakawa K, Miyazawa K, Onozaki K.
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Journal Title
J Interferon & Cytokine Research
Volume: 33
Issue: 6
Pages: 297-307
DOI
Related Report
Peer Reviewed
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[Presentation] Staphylococcal superantigen-like protein 10 (SSL10) binds to vitamin K-dependent blood coagulation factors via their γ-carboxyglutamic acid (Gla) domain and inhibits blood coagulation.2013
Author(s)
Saotomo Itoh, Ryosuke Yokoyama, Go Kamoshida, Toshinobu Fujiwara, Hiromi Okada, Takemasa Takii, Tsutomu Tsuji, Satoshi Fujii, Hideki Hashizume, and Kikuo Onozaki
Organizer
EMBO | EMBL Symposium: New Approaches and Concepts in Microbiology
Place of Presentation
Heidelberg, Germany
Related Report
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