• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of the responsible bacteria of inflammatory bowel disease, and development to the treatment and prevention method.

Research Project

Project/Area Number 25460177
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental and hygienic pharmacy
Research InstitutionAichi Gakuin University

Principal Investigator

kawamura Yoshiaki  愛知学院大学, 薬学部, 教授 (80262757)

Co-Investigator(Renkei-kenkyūsha) Tanaka Kaori  岐阜大学, 生命科学総合研究支援センター, 教授 (20242729)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords微生物学 / 感染症学 / 炎症性腸疾患 / メタゲノム解析 / 細菌叢
Outline of Final Research Achievements

We were able to construct the model mice, and obtain a certain knowledge about the intestinal flora. As for the suspected pathogenic bacteria, the presence or a certain amount of increase or decrease were observed along with the disease state. From these data, it increased the possibility of the causative agent bacteria or bacterial group. In addition, the premedication of a certain antibacterial agent was effective for suppression of the worse disease condition, it was considered to be obtained the knowledge of the medical treatment. Characteristics of the immune response was not able to be undertaken in this study period, but we could construct the measuring system and start to collect the data. The period of this grant was completed, but we will continue this study.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Products Report
  • Research Products

    (19 results)

All 2018 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (2 results)

  • [Journal Article] Paraclostridium bifermentans exacerbates pathosis in a mouse model of ulcerative colitis2018

    • Author(s)
      Kutsuna R, Tomida J, Morita Y, Kawamura Y.
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 5 Pages: e0197668-e0197668

    • DOI

      10.1371/journal.pone.0197668

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Helicobacter cinaedi bacteremia resulting from antimicrobial resistance acquired during treatment for X-linked2016

    • Author(s)
      Meiwa T, Tomida J, Kawamura Y, Miyata I, Yuza Y, Horikoshi Y.
    • Journal Title

      J. Infect Chemother

      Volume: 22 Issue: 10 Pages: 704-706

    • DOI

      10.1016/j.jiac.2016.02.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Profiling subgingival microbiota of plaque biofilms in the elderly.2016

    • Author(s)
      Abiko Y, Sato T, Sakashita R, Tomida J, Kawamura Y, Takahashi N
    • Journal Title

      J Oral Biosci

      Volume: 58 Issue: 2 Pages: 62-65

    • DOI

      10.1016/j.job.2015.12.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Helicobacter cinaediおよびHelicobacter fennelliaeによる感染症2016

    • Author(s)
      富田純子、河村好章
    • Journal Title

      Journal of Helicobacter Research

      Volume: 20

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Porphyromonas pogonae sp. nov., an anaerobic but low concentration oxygen adapted coccobacillus isolated from lizards (Pogona vitticeps) or human clinical specimens, and emended description of the genus Porphyromonas Shah and Collins 19882015

    • Author(s)
      Y. Kawamura, S. Kuwabara, S.A. Kania, H. Kato, M. Hamagishi, N. Fujiwara, T. Sato, J. Tomida, K. Tanaka, D.A. Bemis
    • Journal Title

      Syst. Appl. Microbiol.

      Volume: 38 Issue: 2 Pages: 104-109

    • DOI

      10.1016/j.syapm.2014.11.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] H. cinaediと敗血症2015

    • Author(s)
      河村好章、富田純子、岡本竜哉、澤智裕、赤池孝章
    • Journal Title

      臨床と微生物

      Volume: 42 Pages: 177-182

    • Related Report
      2015 Annual Research Report
  • [Presentation] 同属菌種間にみられたマウスDSS感受性の違い2017

    • Author(s)
      久綱僚、富田純子、森田雄二、河村好章
    • Organizer
      第63回日本細菌学会中部支部総会
    • Related Report
      Products Report
  • [Presentation] Acertain Clostridium sp. might be affected UC model mouse status adversely.2017

    • Author(s)
      Kutsuna R, Tomida J, Morita Y, Kawamura Y.
    • Organizer
      International Union of Microbiological Societies 2017, Singapore
    • Related Report
      Products Report
    • Int'l Joint Research
  • [Presentation] 特定のClostridium sp.はUCモデルマウスにおける病態悪化因子となり得る2017

    • Author(s)
      久綱 僚, 富田 純子, 森田 雄二, 河村 好章
    • Organizer
      日本薬学会第137年会
    • Related Report
      Products Report
  • [Presentation] 腸炎モデルマウス腸内細菌叢に優位に存在するClostridium sp. ID4 による炎症誘発2016

    • Author(s)
      富田純子, 中島健一, 鈴木裕可, 森田雄二, 波多野紀行, 井上誠, 河村好章
    • Organizer
      日本薬学会 第136年回
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 健常者における新興感染症菌Helicobacter cinaedi 感染スクリーニングと感染疫学研究2016

    • Author(s)
      松永 哲郎,藤井 重元,井田 智章,津々木 博康,澤 智裕,河村 好章,赤池 孝章
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府・大阪市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 同一施設から分離されたHelicobacter cinaediの系統解析および環境からの検出調査2016

    • Author(s)
      富田純子、川松亜衣、繁益凪紗、森田雄二、河村好章
    • Organizer
      第27回日本臨床微生物学会総会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-01-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 潰瘍性大腸炎モデルマウス病態増悪因子としてのClostridium sp. ID42016

    • Author(s)
      久綱僚、富田純子、森田雄二、河村好章
    • Organizer
      第53回日本細菌学会中部支部総会
    • Related Report
      Products Report
  • [Presentation] Clostridium sp. ID4のDSS誘発性大腸炎モデルマウス病態への関与2016

    • Author(s)
      久綱僚、富田純子、森田雄二、河村好章
    • Organizer
      第28回微生物シンポジウム
    • Related Report
      Products Report
  • [Presentation] DGGE(変性剤濃度勾配ゲル電気泳動)法を用いたUCモデルマウス腸内細菌叢の構造解析2015

    • Author(s)
      久綱僚、冨田純子、森田雄二、河村好章
    • Organizer
      第61回日本薬学会東海支部総会・大会
    • Place of Presentation
      名古屋市立大学薬学部(愛知県・名古屋市)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] PCR biasを逆利用した16Sメタゲノム精査解析法2015

    • Author(s)
      河村好章
    • Organizer
      第89回日本感染症学会学術講演会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2015-04-16 – 2015-04-17
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] PCR biasを逆利用した16Sメタゲノム精査解析法2015

    • Author(s)
      河村好章
    • Organizer
      第89回日本感染症学会学術講演会
    • Place of Presentation
      京都国際会館(京都府・京都市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Book] 薬学領域の病原微生物学・感染症学・化学療法学 第3版2016

    • Author(s)
      富田純子、森田雄二、河村好章、他
    • Total Pages
      387
    • Publisher
      廣川書店
    • Related Report
      2015 Annual Research Report
  • [Book] Springer2015

    • Author(s)
      Sato T, Kawamura Y, Yamaki K, et al.
    • Total Pages
      6
    • Publisher
      Innovative Research on Biosis-Abiosis Intelligent Interface
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi