Development of a preventive method for noise-induced hearing impairments targeting a new hearing-related molecule
| Project/Area Number |
25460178
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental and hygienic pharmacy
|
|---|
| Research Institution | Nagoya University (2014-2016)
Chubu University (2013) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
Iida machiko 名古屋大学, 大学院医学系研究科, 特任助教 (60465515)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 騒音 / 聴力 / 内耳 / ラセン神経節 / 難聴 |
|---|
| Outline of Final Research Achievements |
This study developed an evaluation system and analyzed c-Ret in spiral ganglion neurons in inner ears in order to obtain a basic data for the development of impairments of inner ears caused by environmental stresses including noise and ototoxic chemicals. Our experimental research showed that oral exposure to manganese caused hearing loss in mice with Ret-mediated neurodegeneration of spiral ganglion neurons (SGNs). Thus, it is possible that the c-Ret is crucial for the development of a method for prevention of impairments of SGNs caused by environmental stresses. Our experimental study with consideration of frequency of noise also showed that exposure of mice to noise caused morphological impairments of vestibule, resulting in imbalance but not hearing loss.
|
Report
(5 results)
Research Products
(46 results)
-
-
-
-
[Journal Article] Transcription factor LSF (TFCP2) inhibits melanoma growth.2016
Author(s)
Goto Y, Yajima I, Kumasaka M, Ohgami N, Tanaka A, Tsuzuki T, Inoue Y, Fukushima S, Ihn H, Kyoya M, Ohashi H, Kawakami T, Bennett DC, Kato M.
-
Journal Title
Oncotarget.
Volume: 19
Issue: 3
Pages: 2739-2790
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation.2016
Author(s)
Kawamoto Y, Ueno Y, Nakahashi E, Obayashi M, Sugihara K, Qiao S, Iida M, Kumasaka MY, Yajima I, Goto Y, Ohgami N, Kato M, Takeda K
-
Journal Title
J Nutr Biochem
Volume: 27
Pages: 112-122
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Epidemiological analysis of the association between hearing and barium in humans2015
Author(s)
Ohgami, N. Mitsumatsu, Y. Ahsan, N. Akhand, A. A. Li, X. Iida, M. Yajima, I. Naito, M. Wakai, K. Ohnuma, S. Kato, M.
-
Journal Title
J Expo Sci Environ Epidemiol
Volume: -
Issue: 5
Pages: 488-493
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
