| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
This study developed an evaluation system and analyzed c-Ret in spiral ganglion neurons in inner ears in order to obtain a basic data for the development of impairments of inner ears caused by environmental stresses including noise and ototoxic chemicals. Our experimental research showed that oral exposure to manganese caused hearing loss in mice with Ret-mediated neurodegeneration of spiral ganglion neurons (SGNs). Thus, it is possible that the c-Ret is crucial for the development of a method for prevention of impairments of SGNs caused by environmental stresses. Our experimental study with consideration of frequency of noise also showed that exposure of mice to noise caused morphological impairments of vestibule, resulting in imbalance but not hearing loss.
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