| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
To investigate the effect of amorphous nanoparticles (AN) on allergic and autoimmune diseases, the nanoparticles were s.c. injected with the antigen ovalbumin (OVA). The results showed that OVA-specific immune responses including Th1, Th2 and Th17 were facilitated by AN. When AN was orally given with OVA before immunization with OVA, induction of OVA-specific oral tolerance was blocked. The blockade of the oral tolerance by AN was associated with the blockade of the suppression of production of Th1, Th2, and Th17 cytokines. Therefore, there is a possibility that the exposure to AN might induce or exacerbate allergic and autoimmune diseases.
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