Effects of amorphous nanoparticles on allergic ashtma and autoimmune diseases
| Project/Area Number |
25460180
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
Yoshino Shin 神戸薬科大学, 薬学部, 教授 (00260729)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 非晶質ナノシリカ / アレルギー / 自己免疫疾患 / アジュバント / 経口免疫寛容 / サイトカイン / 自己免疫 / 炎症 / ナノ粒子 / Th1 / Th2 |
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| Outline of Final Research Achievements |
To investigate the effect of amorphous nanoparticles (AN) on allergic and autoimmune diseases, the nanoparticles were s.c. injected with the antigen ovalbumin (OVA). The results showed that OVA-specific immune responses including Th1, Th2 and Th17 were facilitated by AN. When AN was orally given with OVA before immunization with OVA, induction of OVA-specific oral tolerance was blocked. The blockade of the oral tolerance by AN was associated with the blockade of the suppression of production of Th1, Th2, and Th17 cytokines. Therefore, there is a possibility that the exposure to AN might induce or exacerbate allergic and autoimmune diseases.
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Report
(5 results)
Research Products
(17 results)
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[Journal Article] Roles of basophils and mast cells infiltrating the lung by multiple antigen challenges in asthmatic responses of mice2013
Author(s)
Nabe T., Matsuya K., Akamizu K., Fujita M., Nakagawa T., Shioe M., Kida H., Takiguchi A., Wakamori H., Fujii M., Ishihara K., Akiba S., Mizutani N., Yoshino S., Chaplin DD
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Journal Title
Br. J. Pharmacol.
Volume: 169
Pages: 462-476
Related Report
Peer Reviewed
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