Pharmacokinetics and pharmacodynamics of novel antihyperuricemic drug.
| Project/Area Number |
25460187
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Hira Daiki 滋賀医科大学, 医学部, 特任助教 (50636959)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 個別医療 / 薬物動態 / 薬学 |
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| Outline of Final Research Achievements |
The aim of the present study is to evaluate the influence of renal function and genetic variance of metabolic enzymes of febuxostat on pharmacokinetics and pharmacodynamics of febuxostat.
The population pharmacokinetic analysis from 84 patients shows that renal function and genetic variance of metabolic enzymes (UGT1A1 and CYP2C9) are not influence on pharmacokinetics and pharmacodynamics of febuxostat.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Assessment of Sunitinib-Induced Toxicities and Clinical Outcomes Based on Therapeutic Drug Monitoring of Sunitinib for Patients With Renal Cell Carcinoma. Clin Genitourin Cancer.2015
Author(s)
Noda S, Otsuji T, Baba M, Yoshida T, Kageyama S, Okamoto K, Okada Y, Kawauchi A, Onishi H, Hira D, Morita SY, Terada T
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Journal Title
Clinical Genitourinary Cancer
Volume: in press
Issue: 4
Pages: 350-358
DOI
Related Report
Peer Reviewed
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[Journal Article] The effect of ABCG2 genotype on the population pharmacokinetics of sunitinib in patients with renal cell carcinoma2014
Author(s)
Mizuno T, Fukudo M, Fukuda T, Terada T, Dong M, Kamba T, Yamasaki T, Ogawa O, Katsura T, Inui K, Vinks AA, Matsubara K.
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Journal Title
Ther Drug Monit
Volume: 36
Issue: 3
Pages: 310-316
DOI
Related Report
Peer Reviewed
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[Journal Article] Population pharmacokinetics/pharmacodynamics of erlotinib and pharmacogenomic analysis of plasma and cerebrospinal fluid drug concentrations in Japanese patients with non-small cell lung cancer.2013
Author(s)
Fukudo M, Ikemi Y, Togashi Y, Masago K, Kim YH, Mio T, Terada T, Teramukai S, Mishima M, Inui K, Katsura T.
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Journal Title
Clinical Pharmacokinetics
Volume: 52
Issue: 7
Pages: 593-609
DOI
Related Report
Peer Reviewed
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