Pharmacokinetics and pharmacodynamics of novel antihyperuricemic drug.

• Project/Area Number: 25460187
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Terada Tomohiro 滋賀医科大学, 医学部, 教授 (10324641)
• Co-Investigator(Kenkyū-buntansha): Hira Daiki 滋賀医科大学, 医学部, 特任助教 (50636959)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 個別医療 / 薬物動態 / 薬学

Outline of Final Research Achievements

The aim of the present study is to evaluate the influence of renal function and genetic variance of metabolic enzymes of febuxostat on pharmacokinetics and pharmacodynamics of febuxostat.
The population pharmacokinetic analysis from 84 patients shows that renal function and genetic variance of metabolic enzymes (UGT1A1 and CYP2C9) are not influence on pharmacokinetics and pharmacodynamics of febuxostat.

Research Products

• [Journal Article] Population pharmacokinetics and therapeutic efficacy of febuxostat in patients with severe renal impairment. (2015)
  • Author(s): Daiki Hira, Yugo Chisaki, Satoshi Noda, Hisazumi Araki, Takashi Uzu, Hiroshi Maegawa, Yoshitaka Yano, Shin-ya Morita, and Tomohiro Terada.
  • Journal Title: Pharmacology Volume: 96 Issue: 1-2 Pages: 90-98
  • DOI: 10.1159/000434633
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intestinal and hepatic drug transporters: pharmacokinetic, pathophysiological, and pharmacogenetic roles. (2015)
  • Author(s): Tomohiro Terada, Daiki Hira.
  • Journal Title: Journal of Gastroenterology Volume: 50 Issue: 5 Pages: 508-519
  • DOI: 10.1007/s00535-015-1061-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intestinal and hepatic drug transporters: pharmacokinetic, pathophysiological, and pharmacogenetic roles. (2015)
  • Author(s): Tomohiro Terada, Daiki Hira.
  • Journal Title: Journal of Gastroenterology Volume: .
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Assessment of Sunitinib-Induced Toxicities and Clinical Outcomes Based on Therapeutic Drug Monitoring of Sunitinib for Patients With Renal Cell Carcinoma. Clin Genitourin Cancer. (2015)
  • Author(s): Noda S, Otsuji T, Baba M, Yoshida T, Kageyama S, Okamoto K, Okada Y, Kawauchi A, Onishi H, Hira D, Morita SY, Terada T
  • Journal Title: Clinical Genitourinary Cancer Volume: in press Issue: 4 Pages: 350-358
  • DOI: 10.1016/j.clgc.2015.01.007
  • Peer Reviewed
• [Journal Article] The effect of ABCG2 genotype on the population pharmacokinetics of sunitinib in patients with renal cell carcinoma (2014)
  • Author(s): Mizuno T, Fukudo M, Fukuda T, Terada T, Dong M, Kamba T, Yamasaki T, Ogawa O, Katsura T, Inui K, Vinks AA, Matsubara K.
  • Journal Title: Ther Drug Monit Volume: 36 Issue: 3 Pages: 310-316
  • DOI: 10.1097/ftd.0000000000000025
  • Peer Reviewed
• [Journal Article] Reduction in gastrointestinal toxicity during S-1 monotherapy for patients with gastric cancer by gastric secretion inhibitors. (2014)
  • Author(s): Yugo Chisaki, Satoshi Noda, Daiki Hira, Shin-ya Morita, Yoshitaka Yano, Tomohiro Terada.
  • Journal Title: Biol. Pharm. Bull. Volume: 37 Pages: 1158-1161
  • Peer Reviewed
• [Journal Article] Pharmacokinetic interaction between sorafenib and prednisolone in a patient with hepatocellular carcinoma. (2013)
  • Author(s): Noda S et al.
  • Journal Title: Cancer Chemother. Pharmacol. Volume: 72(1) Issue: 1 Pages: 269-272
  • DOI: 10.1007/s00280-013-2187-9
  • Peer Reviewed
• [Journal Article] Population pharmacokinetics/pharmacodynamics of erlotinib and pharmacogenomic analysis of plasma and cerebrospinal fluid drug concentrations in Japanese patients with non-small cell lung cancer. (2013)
  • Author(s): Fukudo M, Ikemi Y, Togashi Y, Masago K, Kim YH, Mio T, Terada T, Teramukai S, Mishima M, Inui K, Katsura T.
  • Journal Title: Clinical Pharmacokinetics Volume: 52 Issue: 7 Pages: 593-609
  • DOI: 10.1007/s40262-013-0058-5
  • Peer Reviewed
• [Presentation] フェブキソスタットの尿酸低下作用に及ぼす患者背景因子の探索 (2016)
  • Author(s): 小出博義, 平 大樹, 辻本雅之, 峯垣哲也, 森田真也, 西口工司, 寺田智祐
  • Organizer: 日本薬学会 第136年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-03-28
• [Presentation] 腎機能低下患者におけるフェブキソスタットの臨床薬理学的研究 (2016)
  • Author(s): 平 大樹
  • Organizer: 腎疾患と高尿酸血症セミナー2016
  • Place of Presentation: ボストンプラザホテル草津
  • Year and Date: 2016-01-30
• [Presentation] CKD患者におけるフェブキソスタットの薬物動態解析 (2015)
  • Author(s): 寺田智祐, 平 大樹, 地嵜悠吾, 野田哲史, 宇津 貴, 前川 聡, 矢野義孝, 森田真也
  • Organizer: 第58回日本腎臓学会, 2015年6月 (名古屋)
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-06-06
• [Presentation] スニチニブ高血中濃度患者における ABCG2 遺伝子多型解析 (2014)
  • Author(s): 寺田智祐
  • Organizer: 医療薬学フォーラム2014
  • Place of Presentation: 東京
  • Year and Date: 2014-06-28 – 2014-06-29
• [Presentation] 経口マルチキナーゼ阻害剤のPK/PD解析 (2014)
  • Author(s): 寺田智祐、野田哲史
  • Organizer: 第31回日本TDM学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-31 – 2014-06-01
• [Presentation] Individualized pharmacotherapy for oral tyrosine kinase inhibitor (2014)
  • Author(s): Tomohiro Terada
  • Organizer: 2014 the Spring International Convention of The Pharmaceutical Society of Korea
  • Place of Presentation: Seoul, Republic of Korea
  • Year and Date: 2014-04-16 – 2014-04-18
  • Invited
• [Presentation] フェブキソスタットの代謝経路の同定とその臨床的な影響の評価 (2013)
  • Author(s): 平 大樹他
  • Organizer: 医療薬学フォーラム2013/第21回クリニカルファーマシーシンポジウム
  • Place of Presentation: 金沢
• [Presentation] がん薬物療法の個別化アプローチによる副作用軽減
  • Author(s): 寺田 智祐
  • Organizer: 日本薬剤学会 第28年会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 高尿酸血症治療薬フェブキソスタットの薬物動態/薬力学的研究
  • Author(s): 平 大樹
  • Organizer: 第2回腎疾患と高尿酸血症セミナー
  • Place of Presentation: 草津
  • Invited
• [Presentation] 高度腎機能低下患者における高尿酸血症治療薬フェブキソスタットの薬物動態解析
  • Author(s): 平 大樹，森田真也，寺田智祐
  • Organizer: 第30回滋賀医科大学シンポジウム
  • Place of Presentation: 大津
• [Book] 医療薬学 第6版 (堀了平、奥村勝彦、乾賢一/監修) (2014)
  • Author(s): 寺田智祐
  • Total Pages: 478
  • Publisher: 廣川書店