Strategy for the personalized CKD medicine based on the crosstalk between albumin-bound uremic toxin and kidney
Project/Area Number |
25460190
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical pharmacy
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Research Institution | Kumamoto University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Toru 熊本大学, 薬学部, 教授 (90423657)
OTAGIRI MASAKI 崇城大学, 薬学部, 教授 (80120145)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 尿毒素 / 腎障害 / 心血管障害 / 酸化ストレス / 尿毒症物質 / アルブミン / 腎疾患 / 個別化医療 / アルブミン尿 / 脂肪酸 / 血管障害 / NADPH oxidase |
Outline of Final Research Achievements |
Chronic kidney disease (CKD), marked by a progressive loss in renal function, is a leading cause of hemodialysis initiation and cardiovascular disease (CVD). Understanding the molecular mechanism responsible for the progression of CKD and cardiovascular damage regarding crosstalk between the kidney and cardiovascular system is an important issue in controlling the pathogenesis of CKD-CVD. However, the mechanisms involved in CKD-CVD are not well understood. We have been investigating the role of protein-bound uremic toxins, that are difficult to remove by hemodialysis, on the onset and progression of CKD and CVD. Here, we focus on two sulfate conjugated uremic toxins, namely, indoxyl sulfate (IS) and p-cresyl sulfate (PCS), and summarize recent studies that provide new insights on the molecular mechanisms responsible for uremic toxin-induced oxidative tissue damage via a cardiovascular-renal connection.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Comparison of Posttranslational Modification and the Functional Impairment of Human Serum Albumin in Commercial Preparations2016
Author(s)
Miyamura S, Imafuku T, Anraku M, Taguchi K, Yamasaki K, Tominaga Y, Maeda H, Ishima Y, Watanabe H, Otagiri M, Maruyama T
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Journal Title
J Pharm Sci.
Volume: 105
Issue: 3
Pages: 1043-1049
DOI
Related Report
Peer Reviewed
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[Journal Article] The pivotal role of eNOS uncoupling in vascular endothelial dysfunction in patients with heart failure with preserved ejection fraction2015
Author(s)
Yamamoto E, Hirata Y, Tokitsu T, Kusaka H, Sakamoto K, Yamamuro M, Kaikita K, Watanabe H, Hokimoto S, Sugiyama S, Maruyama T, Ogawa H
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Journal Title
Int J Cardiol.
Volume: 190
Pages: 335-337
DOI
Related Report
Peer Reviewed
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[Journal Article] p-Cresyl sulfate, a uremic toxin, causes vascular endothelial and smooth muscle cell damages by inducing oxidative stress.2015
Author(s)
Watanabe H, Miyamoto Y, Enoki Y, Ishima Y, Kadowaki D, Kotani S, Nakajima M, Tanaka M, Matsushita K, Mori Y, Kakuta T, Fukagawa M, Otagiri M, Maruyama T
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Journal Title
Pharmacol Res Perspect
Volume: 3
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nano-antioxidant for the treatment of two acute hepatitis models.2015
Author(s)
Maeda H, Hirata K, Watanabe H, Ishima Y, Chuang VT, Taguchi K, Inatsu A, Kinoshita M, Tanaka M, Sasaki Y, Otagiri M, Maruyama T.
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Journal Title
J Pharmacol Exp Ther
Volume: 352
Issue: 2
Pages: 244-257
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic diseases2014
Author(s)
K. Nagumo, M. Tanaka, VT. Chuang, H. Setoyama, H. Watanabe, N. Yamada, K. Kubota, M. Tanaka, K. Matsushita, A. Yoshida, H. Jinnouchi, M. Anraku, D. Kadowaki, Y. Ishima, Y. Sasaki, M. Otagiri, T. Maruyama.
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Journal Title
PLoS One
Volume: 9
Issue: 1
Pages: e85216-e85216
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Albumin fusion renders thioredoxin an effective anti-oxidative and anti-inflammatory agent for preventing cisplatin-induced nephrotoxicity.2014
Author(s)
Kodama A, Watanabe H, Tanaka R, Kondo M, Chuang VT, Wu Q, Endo M, Ishima Y, Fukagawa M, Otagiri M, Maruyama T.
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Journal Title
Biochim Biophys Acta.
Volume: 1840
Issue: 3
Pages: 1152-1162
DOI
Related Report
Peer Reviewed
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[Journal Article] p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase.2013
Author(s)
Watanabe H, Miyamoto Y, Honda D, Tanaka H, Wu Q, Endo M, Noguchi T, Kadowaki D, Ishima Y, Kotani S, Nakajima M, Kataoka K, Kim-Mitsuyama S, Tanaka M, Fukagawa M, Otagiri M, Maruyama T
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Journal Title
Kidney Int
Volume: 83
Pages: 582-592
Related Report
Peer Reviewed
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[Journal Article] A human serum albumin-thioredoxin fusion protein prevents experimental contrast-induced nephropathy2013
Author(s)
Kodama A, Watanabe H, Tanaka R, Tanaka H, Chuang VT, Miyamoto Y, Wu Q, Endo M, Hamasaki K, Ishima Y, Fukagawa M, Otagiri M, Maruyama T
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Journal Title
Kidney Int
Volume: 83
Pages: 446-454
Related Report
Peer Reviewed
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