| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Aquaporin 10 was found to be capable of transporting major nucleobases (adenine，guanine，cytosine，thymine and uraci1), and also 5-fluorouracil and 6-mercaptopurine, which are drugs derived from nucleobases. The transport of those compounds was suggested not to be saturable, being mediated by its channel-like function. On the other hand, its operation could not be confirmed in the Caco-2 cell as an intestinal epithelial cell model. More detailed studies should be needed to further clarify the potential role of aquaporin 10 in the intestinal absorption of nucleobases and analogous drugs. It may also be needed to examine a possibility that the Caco-2 cell might not be suitable as a model to assess the transport of this class of compounds.
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