| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The flavin-containing monooxygenase 3 (FMO3) catalyzes the oxygenation of N- and S- containing medicines and xenobiotic substances. From viewpoint of growing interest in drug interactions mediated by polymorphic FMO3, benzydamine N-oxygenation and sulindac sulfide S-oxygenation by human liver microsomal FMO3 were investigated as model reactions. Genetic polymorphisms in the human FMO3 gene might lead to some changes of enzyme activities and drug-drug interactions for N- or S-oxygenations of endogenous and xenobiotic substances including medicines. Since even the most common p.[(Glu158Lys; Glu308Gly)] variant FMO3 protein could result in stronger inhibition potential, genetic polymorphism of human FMO3 gene might lead to unexpected drug interactions via modulation of FMO3 catalytic efficiency.
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