| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The purpose of this study was to clarify drug metabolism systems in the brain and the changes in these systems caused by xenobiotics. Drug-metabolizing enzymes were expressed in the rat brain, and their expression was induced by treatment with phenytoin or phenobarbital, which are anti-epileptic agents. Intraperitoneal phenobarbital treatment induced the production of reactive oxygen species that consequently caused the expression of drug-metabolizing enzymes. These changes in expression could affect pharmacological effects of drugs and physiological function of the brain, because of alterations in the concentrations of the drugs and endogenous compounds in the brain.
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