Possibility of drug interaction in the brain caused by changes in drug metabolism
| Project/Area Number |
25460200
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
Katoh Miki 名城大学, 薬学部, 准教授 (70345594)
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| Co-Investigator(Kenkyū-buntansha) |
NADAI Masayuki 名城大学, 薬学部, 教授 (00295544)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 薬物代謝 / グルクロン酸抱合 / UGT / 脳 / 酵素誘導 / UGT1A / 神経細胞 / CYP |
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| Outline of Final Research Achievements |
The purpose of this study was to clarify drug metabolism systems in the brain and the changes in these systems caused by xenobiotics. Drug-metabolizing enzymes were expressed in the rat brain, and their expression was induced by treatment with phenytoin or phenobarbital, which are anti-epileptic agents. Intraperitoneal phenobarbital treatment induced the production of reactive oxygen species that consequently caused the expression of drug-metabolizing enzymes. These changes in expression could affect pharmacological effects of drugs and physiological function of the brain, because of alterations in the concentrations of the drugs and endogenous compounds in the brain.
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Report
(4 results)
Research Products
(11 results)
