| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
The cervical lymph node (CLN) receives the metastasis of the cancer and the inflammation by bacterial or virus infection arising in the head, nose, ear and throat. Our previous investigations suggested that nasal administration to rats enable the direct delivery of some model drugs to CLN. In this study, we investigated the direct transport of some additional model drugs to CLN through the nasal mucosa of mice in order to clarify the physicochemical property of drug suitable for the direct transport to CLN, and the inhibitory effect of the antitumor drug applied nasally on the cancer metastasis to the CLN using an orthotropic implantation mice model.
Intranasal administration is useful for the efficient delivery of drugs such as MTX to the CLN. MTX concentrations after nasal administration were increased in a dose-dependent manner. These findings suggest the feasibility of the effective therapy for the CLN metastasis by nasal administration of antitumor drugs.
|
