| Project/Area Number |
25460205
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HARIMA Meirei 新潟薬科大学, 薬学部, 助手 (20333536)
IZUMIKAWA Takuji 新潟大学, 研究推進機構, 准教授 (60282985)
GOTO Jun 新潟大学, 研究推進機構, 助教 (90370395)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 心臓集積性標識薬剤 / 心臓エネルギー獲得機能 / 心機能評価 / 脂肪酸代謝機能 / 糖代謝機能 / 心不全疾患 / 心機能改善薬 / 糖尿病疾患 / 標識脂肪酸集積性 / 標識糖集積性 / 糖尿病 / 心臓機能 / 腎臓機能 / 放射能分離計測 / 標識脂肪酸 / 心不全慢性期 / 心重量 / 心臓集積性 / 脂肪酸代謝機能改善 / 標識糖 / 脂肪酸代謝 / 糖代謝 / エネルギー獲得機能 |
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| Outline of Final Research Achievements |
We invesitigated the change of the heart energy-getting system on the various heart conditions using the treated animals and heart-accumulated radiopharmaceuticals. In this study, we used three kinds of the treated animals described just below ; rats with chronic heart failure (CHF group), CHF group + heart-function improved agents (agent administration group) and mice with diabetes mellitus (DM group) and used the following three studies ; heart uptake study, fatty acid metabolic study, heart imaging study.
In the study using CHF group, it has been shown that the heart energy-getting system with CHF is shifted from fatty acid use to sugar use. In the study using agent (PV) administration group, it has been shown that the heart-function recovery by PV is caused by the increase of the fatty acid metabolic function. In the study using DM group, it has been shown that with increasing damage by DM, the fatty acid uptake in the heart decreases, and the sugar uptake increases.
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