| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The experimental data obtained from Nagase analbuminemic rats showed that the free mycophenolic acid (MPA) concentration was suitable for the biomarker of immunosuppressive effect of MPA. Simulations based on the obtained pharmacokinetic and pharmacodynamic parameters showed that the pharmacological marker IMPDH activity decreased non-linearly according to the increase in free fraction of MPA, although the area under the concentration-time curve of free MPA increased linearly.Population pharmacokinetic and pharmacodynamic analyses using clinical data obtained from hematopoietic stem cell transplant patients showed that the decreased renal failure increased the MPA concentration by the increased enterohepatic circulation of the accumulated metabolite, but scarcely affected the pharmacological effects.
In conclusion, since the pharmacodynamics of MPA was non-linear, the increased MPA concentration has a limited effect on the pharmacological effects of MPA.
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