Role of Notch Singnaling in the progress of glomerulonephritis
| Project/Area Number |
25460216
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Chubu University (2014-2015)
University of Shizuoka (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 腎炎 / Notch / 酸化ストレス / 糸球体腎炎 / ROS / Thy1腎炎 |
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| Outline of Final Research Achievements |
The number of patients of artificial dialysis has been increasing these days. It is desired that the reduction of new end-stage renal disease in which dialysis is required in terms of both national medical expense and quality of patient’s life. Mesangial proliferative glomerulonephritis is the largest primary disease after diabetic nephropathy. In this study, we have found that transient expression of Notch1 receptor in a rat model of mesangial proliferative glomerulonephritis, suggesting that Notch signaling may be important in the progress of this disease. We have also found that a certain type of hydroxycarbazole have antioxidant capacity and may affect Notch signaling through the crosstalk of intracellular signaling.
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Report
(4 results)
Research Products
(3 results)
