| Project/Area Number |
25460218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
Kimura Kazunori 名古屋市立大学, 医学(系)研究科(研究院), 教授 (00423848)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Yasuhiro 名古屋市立大学, 大学院薬学研究科, 講師 (60275146)
HOTTA Yuji 名古屋市立大学, 大学院薬学研究科, 助教 (90637563)
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Shoichi 名古屋市立大学, 大学院医学研究科, 准教授 (50225869)
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| Research Collaborator |
KATAOKA Tomoya 名古屋市立大学, 大学院医学研究科, 助教 (20737928)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 5α還元酵素阻害剤 / 勃起障害 / 動脈硬化 / 血管内皮機能 / ジヒドロテストステロン / テストステロン / 酸化ストレス / 一酸化窒素 / 勃起不全 / 心血管機能 / 内皮機能 / 前立腺肥大症 |
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| Outline of Final Research Achievements |
5-alpha-reductase inhibitors are used for Androgenetic Alopecia or benign prostatic hyperplasia from 2005. One study reported that 6 months of 5-alpha-reductase inhibitors therapy caused ED at 3 months and at 6 months. Erectile function have close relationship to cardiovascular function. We investigated the erectile function and cardiovascular function in animal model.
5-alpha-reductase inhibitors decreased the erectile function in rats at 4 weeks and 8 weeks. However, the endothelial function of the rats’ aorta was not changed.
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