Development for new targets of anti-depressants using biological clock-system

Research Project

Project/Area Number	25460221
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Medical pharmacy
Research Institution	Jichi Medical University
Principal Investigator	Ushijima Kentaro 自治医科大学, 医学部, 講師 (70448843)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	うつ病 / 生体リズム / 時計遺伝子 / 薬物有害反応 / 薬物友愛反応
Outline of Final Research Achievements	In this study, forced swimming test was performed in mice administered with interferon-alpha, mefloquine, and topiramate which are reported to induce a depressive disorder in clinical situation. Interferon-alpha significantly increased the immobility-time of mice, while mefloquine, and topiramate significantly decreased the time. Behavioral alterations in the forced swimming test were different by drugs used in the present study. Next, expression patterns of clock genes in the brain of mice administered with these drugs. All drugs decreased Per3 mRNA expression levels in the hippocampus, which resulted in the dampening of rhythm amplitude in mRNA expression.