| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
It has been reported that D-serine administration with antipsychotics was effective for the treatment of schizophrenia. An inhibitory effect of D-amino acid oxidase (DAO) activity by several antipsychotics or mood stabilizer etc. was firstly investigated by in vitro experiment, and we found that second-generation antipsychotics, risperidone (Ris) and blonanserin revealed relatively intense inhibitory actions of in vitro DAO activity. Next, Ris followed by D-serine was administered intraperitoneally to rats, and the D-serine levels in rat plasma or brain (striatum) with or without Ris pretreatment were examined by HPLC with fluorescence detection. Consequently, D-serine levels in rat plasma and microdialysis sample from striatum in rat brain were significantly increased in rats pretreated with Ris.
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