| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
This study investigated transdermal delivery and permeability to the brain of resveratrol (RES), which is functional polyphenol contained in red wine. Pterostilbene and acetylpterostilbene were synthesized as a RES derivative, and they were evaluated for their inhibitory activities of melanogenesis in B16 mouse melanoma cells.The amount of accumulated penetrations of RES with the fatty ester C8 in 8 hours increased to the skin by about 12 times as compared with the case where there is no absorption enhancer. We demonstrated that C8 is not only to promote the skin permeability of RES as absorption enhancers, but to have the action which also raises the transportability in the skin simultaneously.Like RES, PTE and the acetyl PTE have melanogenesis inhibition and showed clearly that one of mechanism has tyrosinase activity inhibition.
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