| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Miscarriage and premature birth occur due to an unbalance in the vaginal microbiota. Therefore, novel prevention and therapeutic method should be ble to reconstruct the unbalance in vaginal microbiota. During the last three years, we elucidated the following three issues; 1) Predominant Lactobacillus sp. 1 in pregnant women was identified by comprehensively analyzing vaginal microbiota using pyrosequencing method. 2) Cytotoxicity due to Gardnerella sp. was reduced in the presence of Lactobacillus sp. 1 on HeLa cell and also Lactobacillus sp. 1 inhibited the production of inflammatory cytokine. 3) LAMP (Loop-Mediated Isothermal Amplification) method was developed in order to detect Gardnerella sp. with high sensitivity and rapidly.
These findings suggested that Lactobacillus sp. 1 has become a candidate of probiotics to prevent or treat bacterial vaginosis.
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