Investigation for the mechanism to induce adverse drug reaction from database: Drug transporters involved in the induction.
Project/Area Number |
25460231
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical pharmacy
|
Research Institution | Kyoto Pharmaceutical University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
YANO Yoshitaka 京都薬科大学, 薬学部, 教授 (60437241)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 副作用 / データベース / 腎障害 / トランスポータ / 薬剤性腎障害 |
Outline of Final Research Achievements |
In this investigation, we screened Japanese Adverse Event Report (JADER) database. In addition, mechanism to induce adverse events was examined using in vitro experimental methods. At first, data files disclosed from PMDA was reconstructed to the relational database with File Maker or Microsoft Access. Based on these reconstructed databases, respective adverse events were extracted. It was found that some characteristics of patients were correlated with prognoses of adverse events. In addition, toxicities of the drugs were examined with cultured cells.
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Report
(4 results)
Research Products
(19 results)