Optimization of medical treatments: Reassessment of hormone data in patients with the autoantibodies
| Project/Area Number |
25460232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Shimatsu Akira 京都医療センター, 臨床研究センター, 臨床研究センター長 (90196494)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ホルモン自己抗体 / 甲状腺刺激ホルモン / プロラクチン / インスリン / マクロプロラクチン血症 / マクロ TSH / 潜在性甲状腺機能低下症 / 糖尿病 / マクロTSH / 潜在性甲状線機能低下症 / 自己免疫 / TSH / 自己抗体 |
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| Outline of Final Research Achievements |
Macro TSH was found in 0.5% of patients with subclinical hypothyroidism. The size of macro TSH was >150kDa compared with 28kDa of monomeric TSH. Macro TSH was mostly a complex of TSH with IgG and the bioactivity was found low by the experiment using FRTL5. Three commercially available TSH assay systems (Elecsys, Centaur, Architect) all recognized macro TSH. It was recommended to screen macro TSH before initiating thyroid hormone replacement therapy. Non-IgG type macroprolactin was found to cross-react to Architect assay system that reportedly seldom recognized macroprolactin. Insulin glargine and aspart were found to be more antigenic and be prone to produce anti-insulin antibody in patients with diabetes on insulin therapy.
These antibodies should be examined to understand the pathophysiology and to provide better treatments for many patients.
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Report
(4 results)
Research Products
(17 results)
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[Presentation] マクロTSH血症の検討2014
Author(s)
服部尚樹、才木康彦、石原 隆、島津 章
Organizer
第８７回日本内分泌学会学術総会
Place of Presentation
福岡国際会議場（福岡県）
Year and Date
2014-04-24
Related Report
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