• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Estimation for the adequate dose of nicotine by using the ratio of the metabolites in urine

Research Project

Project/Area Number 25460235
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionHiroshima International University

Principal Investigator

Tayama Yoshitaka  広島国際大学, 薬学部, 講師 (80389121)

Co-Investigator(Kenkyū-buntansha) SANHO Seigo  広島大学, 大学院医歯薬総合研究科, 助教 (00552267)
SUGIHARA Kazumi  広島国際大学, 薬学部, 教授 (20271067)
TANIGUCHI Yoshihiko  広島国際大学, 薬学部, 教授 (30403520)
KITAMURA Shigeyuki  日本薬科大学, 薬学部, 教授 (40136057)
OHOTA Shigeru  広島大学, 大学院医歯薬総合研究科, 教授 (60160503)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords医療薬学 / ニコチン製剤 / nicotine / aldehyde oxidase / CYP2A6 / ニコチン / 禁煙治療 / 薬物代謝酵素
Outline of Final Research Achievements

The purpose of our study is to estimate for the adequate dose of nicotine by using the ratio of the metabolites in urine. We could determine the nicotine and the metabolites (cotinine, 3’-hydroxycotinine) in rats urine semi-quantitatively, by using new methods (combination of the TLC isolation and the color identification of nicotine analogs).
However, it was not enough to determine their concentration in human urine. We suggest that the contaminant of urine, such as bilirubin, interfere with the color identification of nicotine analogs, and then it was not enough to determine the nicotine metabolites. In future plane, we will investigate by using saliva instead of urine.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results)

  • [Journal Article] Effect of Bakumondo-to on cytochrome P450 activities in rat liver microsomes2016

    • Author(s)
      Masako Yasuhara, Yoshitaka Tayama, Takehiro Kashiwagi, Akihiro Sawa, Kenji Kihira, Katsushi Miyake
    • Journal Title

      Journal of King Saud University - Science

      Volume: 28 Issue: 2 Pages: 198-202

    • DOI

      10.1016/j.jksus.2016.02.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CYP2B6とブプロピオン禁煙治療 ヒドロキシブプロピオンの役割とは2013

    • Author(s)
      田山剛崇
    • Journal Title

      ファルマシア

      Volume: 49(12) Pages: 1206-1206

    • NAID

      110009995670

    • Related Report
      2013 Research-status Report
  • [Presentation] Allopurinol代謝に及ぼすaldehyde oxidase活性の影響~ラット in vivoにおける検討~2015

    • Author(s)
      田山剛崇、杉原数美、三宅勝志、北村繁幸、太田 茂
    • Organizer
      日本薬学会 第135年回
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] ラット in vivo におけるallopurinol代謝へのxanthine oxidase およびaldehyde oxidase活性の影響2014

    • Author(s)
      田山剛崇、杉原数美、三宅勝志、北村繁幸、太田 茂
    • Organizer
      第24回 日本医療薬学会年回
    • Place of Presentation
      名古屋
    • Year and Date
      2014-09-27 – 2014-09-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Allopurinol代謝におけるaldehyde oxidase活性の寄与に関する検討2014

    • Author(s)
      田山剛崇,杉原数美,三宅勝志,北村繁幸,太田 茂
    • Organizer
      日本薬学会 第134年回
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi