Estimation for the adequate dose of nicotine by using the ratio of the metabolites in urine
| Project/Area Number |
25460235
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Hiroshima International University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SANHO Seigo 広島大学, 大学院医歯薬総合研究科, 助教 (00552267)
SUGIHARA Kazumi 広島国際大学, 薬学部, 教授 (20271067)
TANIGUCHI Yoshihiko 広島国際大学, 薬学部, 教授 (30403520)
KITAMURA Shigeyuki 日本薬科大学, 薬学部, 教授 (40136057)
OHOTA Shigeru 広島大学, 大学院医歯薬総合研究科, 教授 (60160503)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 医療薬学 / ニコチン製剤 / nicotine / aldehyde oxidase / CYP2A6 / ニコチン / 禁煙治療 / 薬物代謝酵素 |
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| Outline of Final Research Achievements |
The purpose of our study is to estimate for the adequate dose of nicotine by using the ratio of the metabolites in urine. We could determine the nicotine and the metabolites (cotinine, 3’-hydroxycotinine) in rats urine semi-quantitatively, by using new methods (combination of the TLC isolation and the color identification of nicotine analogs).
However, it was not enough to determine their concentration in human urine. We suggest that the contaminant of urine, such as bilirubin, interfere with the color identification of nicotine analogs, and then it was not enough to determine the nicotine metabolites. In future plane, we will investigate by using saliva instead of urine.
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Report
(4 results)
Research Products
(5 results)
