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Evaluation of interaction between biotechnology-based drug and chemical drug using medical information databases

Research Project

Project/Area Number 25460239
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionNational Institute of Health Sciences

Principal Investigator

SAI KIMIE  国立医薬品食品衛生研究所, 医薬安全科学部, 室長 (20195960)

Co-Investigator(Kenkyū-buntansha) KAWAKAMI JUN-ICHI  浜松医科大学, 医学部附属病院, 教授・薬剤部長 (50272539)
HORI KATSUHITO  浜松医科大学, 医学部附属病院, 副薬剤部長 (20436786)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords医療情報データベース / 薬物間相互作用 / 免疫バイオ医薬品 / スタチン / 免疫関連バイオ医薬品
Outline of Final Research Achievements

To investigate interactions between biotechnology-based drug and chemical drug, we established an assessment method using medical information databases and applied it to evaluate a possible interaction between statin drugs and antibody drugs for IL-6 receptor and TNFα or TNF receptor drugs. Changes in any indices for statin related efficacy or adverse reactions after co-administration with these biotechnology-based drugs were almost equivalent to those after treatment with these drugs alone. This finding indicated that interactions between statins and these biotechnology-based drugs might be ignorable under the clinical setting in Japan.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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