| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
In this study, we found the new cardiac precursor population, which contributes to all heart components except for the right ventricle, by expression and lineage analysis of the gene related to the Wnt signaling. Studies with the knockout mice and cell culture system showed that Wnt signaling could regulate proliferation of the precursor cells rather than differentiation to the myocardium. Since Wnt signaling could not affect differentiation, the establishment of a culture system that maintained the undifferentiated state of cardiac precursor cells remained as a future assignment.
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