Functional analysis of cardiac precursor cells
| Project/Area Number |
25460244
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Hiroshima University |
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Principal Investigator |
Kokubo Hiroki 広島大学, 医歯薬保健学研究院(医), 講師 (10270480)
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| Co-Investigator(Kenkyū-buntansha) |
吉栖 正生 広島大学, 医歯薬保健学研究院, 教授 (20282626)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 心筋 |
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| Outline of Final Research Achievements |
In this study, we found the new cardiac precursor population, which contributes to all heart components except for the right ventricle, by expression and lineage analysis of the gene related to the Wnt signaling. Studies with the knockout mice and cell culture system showed that Wnt signaling could regulate proliferation of the precursor cells rather than differentiation to the myocardium. Since Wnt signaling could not affect differentiation, the establishment of a culture system that maintained the undifferentiated state of cardiac precursor cells remained as a future assignment.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Osteoprotegerin Prevents Development of Abdominal Aortic Aneurysms.2016
Author(s)
Bumdelger B, Kokubo H, Kamata R, Fujii M, Yoshimura K, Aoki H, Orita Y, Ishida T, Ohtaki M, Nagao M, Ishida M, Yoshizumi M.
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Journal Title
PLoS One
Volume: 11
Issue: 1
Pages: 147088-147107
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Evidence of Notch-Hesr-Nrf2 Axis in Muscle Stem Cells, but Absence of Nrf2 Has No Effect on Their Quiescent and Undifferentiated Stat2015
Author(s)
Yamaguchi M, Murakami S, Yoneda T, Nakamura M, Zhang L, Uezumi A, Fukuda S, Kokubo H, Tsujikawa K, Fukada S
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Journal Title
PLoS One
Volume: 10(9)
Issue: 9
Pages: 138517-138531
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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