| Project/Area Number |
25460246
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Kumamoto University |
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Principal Investigator |
YOSHINAGA KAZUYA 熊本大学, 大学院生命科学研究部(保), 教授 (50136719)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Kentaro 和歌山県立医科大学, 先端医学研究所, 講師 (20404345)
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| Research Collaborator |
MURAKAMI Kana 熊本大学, 大学院保健学教育部, 大学院生
YOSHIDA Ayaka 熊本大学, 大学院保健学教育部, 大学院生
SAKUDA Kentaro 熊本大学, 大学院保健学教育部, 大学院生
MURAGISHI Ryoki 熊本大学, 大学院保健学教育部, 大学院生
KAWABATA Yusei 熊本大学, 大学院保健学教育部, 大学院生
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| Project Period (FY) |
2013-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 細胞・組織 / 発生・分化 / 男性生殖器 / 精巣上体 / タイト結合 |
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| Outline of Final Research Achievements |
To elucidate the mechanism of development and differentiation of male reproductive organs, we examined the immunohistochemical expression and localization of cell surface sugar chains and cytoskeletal molecules in the epididymis and prostate during fetal and postnatal development of mice. We found that the distribution and localization patterns of lectin-binding sites, proton secretion-related molecules, and cytokeratin molecules are different depending on each epithelial region, differentiation stage or cell type. We also showed that some sugar chain structures and molecules may provide useful markers for research into cell differentiation.
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