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Sequential morphogenetic changes of lymphatic endothelium caused by molecular genetic cues

Research Project

Project/Area Number 25460249
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including histology/embryology)
Research InstitutionIwate Medical University

Principal Investigator

ISOGAI SUMIO  岩手医科大学, 医学部, 准教授 (60212966)

Co-Investigator(Kenkyū-buntansha) SHIMODA HIROSHI  弘前大学, 医学研究科, 教授 (20274748)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsリンパ管 / 小型魚類 / リンパ管発生 / 胸管 / ゼブラフィッシュ / Arrey Tomography / ミュータント / メダカ / 肺魚 / モデル動物
Outline of Final Research Achievements

As well known, lymph-endothelial cells are originated from venous endothelia in zebrafish and medaka embryos. We investigated sequential phenotypic changes which are closely related with the molecular genetic changes to become the lymph endothelium from the venous endothelium.
1. We compiled the anatomical atlas of lymph vascular systems in zebrafish and medaka from embryos through adults.2. We investigated the sequential morphogenetic changes of lymph-endothelial cells with Arrey Tomography.3. Using VEGFR3 mutant zebrafish, we analyzed developmental mechanisms of cervical lymph-sac.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results) (of which Invited: 4 results) Book (1 results)

  • [Journal Article] Integration of vascular systems between the brain and spinal cord in zebrafish2015

    • Author(s)
      Kimura E., Isogai S., Hitomi J
    • Journal Title

      Developmental Biology

      Volume: 406 Pages: 40-51

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒトの血管とリンパ管に残された謎を魚で解く2015

    • Author(s)
      磯貝純夫
    • Organizer
      第24回日本形成外科学会基礎学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 小型魚類のリンパ輸送経路2015

    • Author(s)
      齊藤絵里奈, 磯貝純夫, 成田大一, 岡野大輔, 浅野義哉, 下田浩
    • Organizer
      第39回日本リンパ学会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-03-27 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Morphogenetic mechanisms of the lymphatic endothelial cells in zebrafish and medaka.2015

    • Author(s)
      Isogai Sumio
    • Organizer
      第120回日本解剖学会総会全国学術集会、解剖学会生理学会合同大会2015シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Novel mechanisms involved in the endothelial differentiation of arteries and veins during vasculogenesis and angiogenesis.2015

    • Author(s)
      Erina Saito, Sumio Isogai, Eiji Kimura, Hiroshi Shimoda, Jiro Hitomi
    • Organizer
      第120回日本解剖学会総会全国学術集会、解剖学会生理学会合同大会2015シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] リンパ管内皮の始原的特性2015

    • Author(s)
      磯貝純夫
    • Organizer
      リンパ・免疫系懇話会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Angioblast takes different way whether it becomes an artery or a vein in the endothelial differentiation and the tube formation.2014

    • Author(s)
      Sumio Isogai, Erina Saito, Eiji Kimura, Jiro Hitomi
    • Organizer
      North American Vascular Biology
    • Place of Presentation
      USA CA
    • Year and Date
      2014-10-18 – 2014-10-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 小型魚類リンパ管の標識法の開発2014

    • Author(s)
      磯貝純夫
    • Organizer
      第65回日本動物学会
    • Place of Presentation
      仙台
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Book] 細胞2015

    • Author(s)
      磯貝純夫
    • Total Pages
      4
    • Publisher
      ニューサイエンス社
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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