Sequential morphogenetic changes of lymphatic endothelium caused by molecular genetic cues
Project/Area Number |
25460249
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General anatomy (including histology/embryology)
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Research Institution | Iwate Medical University |
Principal Investigator |
ISOGAI SUMIO 岩手医科大学, 医学部, 准教授 (60212966)
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Co-Investigator(Kenkyū-buntansha) |
SHIMODA HIROSHI 弘前大学, 医学研究科, 教授 (20274748)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | リンパ管 / 小型魚類 / リンパ管発生 / 胸管 / ゼブラフィッシュ / Arrey Tomography / ミュータント / メダカ / 肺魚 / モデル動物 |
Outline of Final Research Achievements |
As well known, lymph-endothelial cells are originated from venous endothelia in zebrafish and medaka embryos. We investigated sequential phenotypic changes which are closely related with the molecular genetic changes to become the lymph endothelium from the venous endothelium. 1. We compiled the anatomical atlas of lymph vascular systems in zebrafish and medaka from embryos through adults.2. We investigated the sequential morphogenetic changes of lymph-endothelial cells with Arrey Tomography.3. Using VEGFR3 mutant zebrafish, we analyzed developmental mechanisms of cervical lymph-sac.
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Report
(4 results)
Research Products
(9 results)
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[Presentation] 小型魚類のリンパ輸送経路2015
Author(s)
齊藤絵里奈, 磯貝純夫, 成田大一, 岡野大輔, 浅野義哉, 下田浩
Organizer
第39回日本リンパ学会総会
Place of Presentation
東京
Year and Date
2015-03-27 – 2015-03-28
Related Report
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[Book] 細胞2015
Author(s)
磯貝純夫
Total Pages
4
Publisher
ニューサイエンス社
Related Report