Role of the relation between morphology and function of sensory neuron in the development and evolution of sensory architecture

• Project/Area Number: 25460251
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Jichi Medical University
• Principal Investigator: YAJIMA Hiroshi 自治医科大学, 医学部, 講師 (10433583)
• Co-Investigator(Renkei-kenkyūsha): TAMURA Koji 東北大学, 生命科学研究科, 教授 (70261550)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 発生 / 進化 / 分化 / 一次感覚神経 / 脊髄神経節 / 神経堤細胞 / エンハンサー / Six遺伝子 / 甲状腺ホルモン / Neuropilin

Outline of Final Research Achievements

We found 1) the developmental mechanism assigning the location of sensory neuron inside or outside spinal cord is cell-autonomous manner and acts independently of the mechanism which defines or maintains the integrity of the boundary structure between the CNS and PNS, 2) Six1 controls the mechanism and relates it to gangliogenesis of sensory neuron via Neuropilin-Semaphorin pathway and 3) urodele amphibians might have a transitional sensory architecture followed by the exclusive DRG system acquired in amniote.

Research Products

• [Journal Article] Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice (2016)
  • Author(s): Yajima H. and Kawakami K.
  • Journal Title: Development Growth and Differentiation Volume: 58/5
  • Peer Reviewed / Open Access
• [Journal Article] Activation of Six1 Expression in Vertebrate Sensory Neurons. (2015)
  • Author(s): Sato S*, Yajima H, Furuta Y, Ikeda K, Kawakami K.
  • Journal Title: PLoS One Volume: Aug 27;10(8) Issue: 8 Pages: 1-21
  • DOI: 10.1371/journal.pone.0136666
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Six1 is a key regulator of the developmental and evolutionary architecture of sensory neurons in craniates (2014)
  • Author(s): H. Yajima, M. Suzuki, H. Ochi, K. Ikeda, S. Sato, K. Yamamura, H. Ogino, N. Ueno and K. Kawakami
  • Journal Title: BMC Biol Volume: 12 Issue: 1 Pages: 40-40
  • DOI: 10.1186/1741-7007-12-40
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 脊椎動物体幹部感覚神経進化におけるSix1遺伝子の役割 (2015)
  • Author(s): 矢嶋浩, 佐藤滋, 林利憲, 小柴和子, 竹内隆, 川上潔
  • Organizer: 日本動物学会第86回大会
  • Place of Presentation: 朱鷺メッセ（新潟市）
  • Year and Date: 2015-09-17
  • Int'l Joint Research
• [Presentation] A missing link in the evolution of sensory architecture in craniates (2015)
  • Author(s): 矢嶋浩, 佐藤滋, 林利憲, 竹内隆, 川上潔
  • Organizer: 日本発生生物学会 第48回大会
  • Place of Presentation: つくば国際会議場（つくば市）
  • Year and Date: 2015-06-02
  • Int'l Joint Research
• [Presentation] マウス髄内一次感覚神経様細胞の成り立ちから考える脊椎動物一次感覚神経の進化 (2014)
  • Author(s): 矢嶋浩、佐藤滋、川上潔
  • Organizer: 日本動物学会第85回大会
  • Place of Presentation: 東北大学川内北キャンパス
  • Year and Date: 2014-09-13
• [Remarks] 自治医科大学・分子病態治療研究センター細胞生物研究部
  • URL: http://www.jichi.ac.jp/biol/home.html
• [Remarks] 自治医科大学・教員業績データベース
  • URL: http://kyouingyousekidb.jichi.ac.jp/profile/ja.81bf6dbfecfc0b6d.html
• [Remarks] researchmap
  • URL: http://researchmap.jp/hyajima/
• [Remarks] Google Scholar
  • URL: http://scholar.google.co.jp/citations?user=AJw8dKYAAAAJ&hl=ja
• [Remarks] 自治医科大学・研究業績データベース
  • URL: http://kyouingyousekidb.jichi.ac.jp/profile/ja.81bf6dbfecfc0b6d.html
• [Remarks] 自治医科大学・分子病態治療研究センター・細胞生物研究部
  • URL: http://www.jichi.ac.jp/biol/home.html
• [Remarks] 自治医科大学・研究シーズ集・研究者詳細
  • URL: http://rseeds.jichi.ac.jp/research_seeds/public/ResearchResultDetail.php?publicId=9f6lyICrrIM78bNVyQCS3U8LQcN2RS&resultCd=1&sectionCd=126