Role of the relation between morphology and function of sensory neuron in the development and evolution of sensory architecture
| Project/Area Number |
25460251
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General anatomy (including histology/embryology)
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TAMURA Koji 東北大学, 生命科学研究科, 教授 (70261550)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 発生 / 進化 / 分化 / 一次感覚神経 / 脊髄神経節 / 神経堤細胞 / エンハンサー / Six遺伝子 / 甲状腺ホルモン / Neuropilin |
|---|
| Outline of Final Research Achievements |
We found 1) the developmental mechanism assigning the location of sensory neuron inside or outside spinal cord is cell-autonomous manner and acts independently of the mechanism which defines or maintains the integrity of the boundary structure between the CNS and PNS, 2) Six1 controls the mechanism and relates it to gangliogenesis of sensory neuron via Neuropilin-Semaphorin pathway and 3) urodele amphibians might have a transitional sensory architecture followed by the exclusive DRG system acquired in amniote.
|
Report
(4 results)
Research Products
(13 results)
