| Project/Area Number |
25460265
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
Yi Shuang-Qin 首都大学東京, 人間健康科学研究科, 教授 (70334753)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yasuhiko 金沢大学, 医学系, 教授 (20313637)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 腸間膜脂肪蓄積 / 脂肪幹細胞 / 脂肪移植 / Gold Thiglucose / Pioglitazone / Gold Thioglucose / 腸間膜脂肪 / pioglitazone / 内臓脂肪蓄積 / gold thioglucose / Suncus murinus / 皮下脂肪 / スンクス / 分化誘導 |
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| Outline of Final Research Achievements |
The adipocyte precursor cells existed with the epididymal, retroperitoneal, and subcutaneous white adipose tissue, but not in the mesentery in Suncus murinus. As a result of isolating a cell from a mesentery of the Suncus, and having cultured it, it did not differentiate to a maturity adipose cell at all.
In a fat transplant experiment of the Suncus, it did not lead to differentiation of the mesenteric tissues by transplanting a mesentery tissue under subcutaneous environment. There was little reduction of food consumption of the Suncus in a high-fat meal, however, as the caloric intake did not change to general meal every day, there was not the change of the weight, and there was not the formation of the mesenteric adipose. It was suggested that the Suncus had resistance for caloric load.
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